{"id":"W2890325820","doi":"10.1038/s41586-018-0436-0","title":"The genetic basis and cell of origin of mixed phenotype acute leukaemia","year":2018,"lang":"en","type":"article","venue":"Nature","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":374,"is_retracted":false,"has_abstract":false,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; BC Cancer Agency","funders":"National Institute of General Medical Sciences; National Cancer Institute; U.S. Department of Health and Human Services; National Institutes of Health; Canada's Michael Smith Genome Sciences Centre; American Lebanese Syrian Associated Charities; St. Jude Children's Research Hospital","keywords":"Myeloid; Haematopoiesis; Biology; Phenotype; Cancer research; Genetic heterogeneity; Somatic cell; Immunology; B cell; Stem cell; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000362838,0.0002103006,0.0004181766,0.001081515,0.0003114838,0.001033914,0.0004273323,0.0006103247,0.002629767],"category_scores_gemma":[0.0009488256,0.0002386764,0.0002203171,0.0004200942,0.0004315447,0.0004641869,0.0007122556,0.0007057734,0.0007621341],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003504139,"about_ca_system_score_gemma":0.0001907051,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002623418,"about_ca_topic_score_gemma":0.0002389337,"domain_scores_codex":[0.9995369,0.0001629317,0.00004560841,0.00005403483,0.0001160345,0.00008449998],"domain_scores_gemma":[0.9994947,0.0001665888,0.0001328042,0.00008188174,0.00004440597,0.00007954375],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002511689,0.0001816578,0.08188453,0.0001426979,0.0001310221,0.006756473,0.0005529192,0.0006789853,0.8444015,0.02911491,0.001013238,0.03263032],"study_design_scores_gemma":[0.0004053116,0.001550388,0.3972368,0.0001410796,0.0007064063,0.08032564,0.002181282,0.009528403,0.4330422,0.02153372,0.05326831,0.00008048588],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9880838,0.00279162,0.002890557,0.0006455169,0.00006275236,0.0000383551,0.0004313023,0.00008229446,0.004973744],"genre_scores_gemma":[0.9977841,0.0005592579,0.0005991313,0.00007697815,0.00003210929,0.0000143839,0.0001744533,0.00001937808,0.0007401643],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002629767,"threshold_uncertainty_score":0.008797407,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01005525437862627,"score_gpt":0.2942993459725573,"score_spread":0.284244091593931,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}