{"id":"W2890364568","doi":"10.1038/s41551-018-0284-0","title":"Restoration of tumour-growth suppression in vivo via systemic nanoparticle-mediated delivery of PTEN mRNA","year":2018,"lang":"en","type":"article","venue":"Nature Biomedical Engineering","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":338,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Waterloo","funders":"National Cancer Institute; National Heart, Lung, and Blood Institute","keywords":"PTEN; Tensin; Prostate cancer; Cancer research; PI3K/AKT/mTOR pathway; Protein kinase B; Biology; Prostate; Tumor suppressor gene; In vivo; Cancer; Medicine; Internal medicine; Cell biology; Signal transduction; Carcinogenesis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002323884,0.0004777678,0.0003034573,0.00026735,0.0001891587,0.0003557559,0.0002371426,0.0004333844,0.001132559],"category_scores_gemma":[0.0001323148,0.000190611,0.000306565,0.0001403575,0.0004732039,0.000334787,0.0001958377,0.0007360522,0.000300606],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004377434,"about_ca_system_score_gemma":0.0004101701,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009375901,"about_ca_topic_score_gemma":0.0009990742,"domain_scores_codex":[0.9998268,0.00001601785,0.00001019892,0.00004622779,0.00005436668,0.00004639354],"domain_scores_gemma":[0.9999268,0.00001540771,0.00002485821,0.000008337995,0.000008184948,0.00001634837],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001144951,0.00003806635,0.00004065973,0.00002704784,0.000004510881,0.0000371535,0.00001535903,0.0001726012,0.9979014,0.0003120793,0.00006258646,0.001274063],"study_design_scores_gemma":[0.00001884121,0.0002168491,0.0002485315,0.000001627924,0.00001394575,0.00006614994,0.000006452216,0.001026258,0.9974952,0.00004262599,0.0008606308,0.000003022913],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9778633,0.001159311,0.0155997,0.000381833,0.0001131559,0.0000850088,0.0003214945,0.0004776674,0.003998498],"genre_scores_gemma":[0.9924022,0.0005473348,0.003011535,0.00004766522,0.00001487599,0.00004617413,0.0001720586,0.000056823,0.003701382],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001132559,"threshold_uncertainty_score":0.003788769,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003536973200859456,"score_gpt":0.2203814483478002,"score_spread":0.2168444751469407,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}