{"id":"W2890387609","doi":"10.1038/s41598-018-31822-7","title":"Metabolic gene expression and epigenetic effects of the ketone body β-hydroxybutyrate on H3K9ac in bovine cells, oocytes and embryos","year":2018,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Diet and metabolism studies","field":"Medicine","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Fundação de Amparo à Pesquisa do Estado de São Paulo","keywords":"Epigenetics; Blastocyst; Somatic cell nuclear transfer; Somatic cell; Biology; Histone; Acetylation; Cell biology; Oocyte; Histone H3; Embryo; Genetics; Embryogenesis; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007504667,0.0001672736,0.0004184852,0.0001824604,0.0001909648,0.00004856098,0.00007179214,0.00005543496,0.00001374473],"category_scores_gemma":[0.0003094403,0.0001009874,0.00005576115,0.0003777658,0.0007098202,0.00006964538,0.0002270837,0.0000966822,0.000003152471],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008553832,"about_ca_system_score_gemma":0.00006559261,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000035981,"about_ca_topic_score_gemma":0.00001665536,"domain_scores_codex":[0.9983326,0.00006843156,0.0003920464,0.0005618745,0.0003841224,0.0002609847],"domain_scores_gemma":[0.9988402,0.00005738104,0.0002202075,0.0006592557,0.0001133792,0.0001096434],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006041432,0.0001200991,0.02375355,0.0001266129,0.00002016917,0.00006695683,0.0006126846,5.473849e-7,0.9725259,0.00001591837,0.001492881,0.001204288],"study_design_scores_gemma":[0.0004001762,0.0001242262,0.2410128,0.0002060682,0.00007821534,0.00002140163,0.00002246205,0.00001852127,0.7521092,0.0003574156,0.005573087,0.00007637579],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9876868,0.007267691,0.000004364539,0.0001278113,0.003549845,0.0005983783,0.000001456189,0.00001681436,0.0007468598],"genre_scores_gemma":[0.9956269,0.0004943502,0.0001423002,0.00006225789,0.0001248456,0.0000223697,0.000002702475,0.00001421971,0.003510083],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2204167,"threshold_uncertainty_score":0.4118146,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007819767059641125,"score_gpt":0.2419705726000862,"score_spread":0.234150805540445,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}