{"id":"W2890407452","doi":"10.1242/jcs.219766","title":"Regulated reconstitution of spindle checkpoint arrest and silencing through chemically induced dimerisation <i>in vivo</i>","year":2018,"lang":"en","type":"article","venue":"Journal of Cell Science","topic":"Microtubule and mitosis dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Medical Research Council; Darwin Trust of Edinburgh; Medical Research Council Canada; Wellcome Trust","keywords":"Biology; Kinetochore; Spindle checkpoint; G2-M DNA damage checkpoint; Cell biology; Cell cycle checkpoint; Gene silencing; Mitosis; Genetics; Cell cycle; Cancer; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002730953,0.0004643681,0.0002263012,0.000210508,0.0001960706,0.0004010903,0.0004835817,0.0003546319,0.001357782],"category_scores_gemma":[0.0001423999,0.0002807014,0.0003065515,0.0001678234,0.0004055939,0.0002762601,0.0003591421,0.0008703094,0.0007867628],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006502003,"about_ca_system_score_gemma":0.0002601197,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007206522,"about_ca_topic_score_gemma":0.0009688119,"domain_scores_codex":[0.999793,0.00004199419,0.00002902164,0.00005341124,0.00005013662,0.0000323431],"domain_scores_gemma":[0.9997522,0.00004641703,0.00008716749,0.00004826396,0.00001942671,0.00004651709],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002460341,0.00001514008,0.00003459338,0.00001661464,0.000002907317,0.00001177434,0.000008460786,0.00005304265,0.999319,0.0001723093,0.00002581176,0.0003157819],"study_design_scores_gemma":[0.00000845449,0.00004526604,0.0003522465,0.000002283957,0.000004209734,0.00005049589,0.000006625989,0.0006387179,0.9970861,0.00002422935,0.001778645,0.000002857749],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9623525,0.0009241406,0.03107028,0.0002076717,0.000111389,0.0001785206,0.001289064,0.0005696507,0.00329682],"genre_scores_gemma":[0.9829603,0.0005312804,0.01072809,0.00008191069,0.00001440338,0.0001134842,0.001455967,0.0002573123,0.003857219],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001357782,"threshold_uncertainty_score":0.004717529,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009638058216686384,"score_gpt":0.2461653596663312,"score_spread":0.2365273014496448,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}