{"id":"W2890422552","doi":"10.1210/jc.2018-00544","title":"The HMGA2-IMP2 Pathway Promotes Granulosa Cell Proliferation in Polycystic Ovary Syndrome","year":2018,"lang":"en","type":"article","venue":"The Journal of Clinical Endocrinology & Metabolism","topic":"Ovarian function and disorders","field":"Medicine","cited_by":65,"is_retracted":false,"has_abstract":true,"ca_institutions":"Child and Family Research Institute; University of British Columbia","funders":"National Institutes of Health; Natural Science Foundation of Shandong Province; National Natural Science Foundation of China; Eunice Kennedy Shriver National Institute of Child Health and Human Development; Shandong University","keywords":"Polycystic ovary; HMGA2; Gene knockdown; Granulosa cell; Biology; Cell growth; Endocrinology; Messenger RNA; Internal medicine; Ovary; Cell culture; Gene; Medicine; Genetics; microRNA; Insulin resistance","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002758264,0.0001904333,0.0007328304,0.0001773734,0.0002214844,0.00002415084,0.0003434558,0.0001610979,0.0001505336],"category_scores_gemma":[0.002230832,0.00009413931,0.0002866519,0.000305289,0.0007653766,0.0001243095,0.00006897613,0.001227088,0.0001262096],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001594971,"about_ca_system_score_gemma":0.0004102994,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001895862,"about_ca_topic_score_gemma":0.0000295158,"domain_scores_codex":[0.9962958,0.001023892,0.001661406,0.000181189,0.000383033,0.0004547088],"domain_scores_gemma":[0.9970993,0.001246467,0.0007051411,0.000442941,0.0003246756,0.0001814455],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.07916262,0.01067587,0.2111019,0.0002241369,0.003131772,0.003457221,0.005928023,0.00004753014,0.0117623,0.02514217,0.03053224,0.6188343],"study_design_scores_gemma":[0.01858522,0.004655981,0.8074474,0.0001120981,0.001044104,0.009391661,0.001008988,0.000367505,0.003587355,0.01137076,0.1421061,0.0003228097],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9690466,0.003652612,0.0006167452,0.02085138,0.00287168,0.0004808881,0.000001952913,0.00002778505,0.00245038],"genre_scores_gemma":[0.9933794,0.001228334,0.0002653536,0.002726172,0.001376515,0.00000682116,0.000001482785,0.00002125703,0.0009947007],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6185114,"threshold_uncertainty_score":0.5331154,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03445562040443764,"score_gpt":0.3339919656984175,"score_spread":0.2995363452939799,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}