{"id":"W2890429581","doi":"10.1002/ijc.31841","title":"Prevalence of <i>BRCA1</i> and <i>BRCA2</i> pathogenic variants in a large, unselected breast cancer cohort","year":2018,"lang":"en","type":"article","venue":"International Journal of Cancer","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Centre hospitalier universitaire de Québec","funders":"Canadian Institutes of Health Research; National Institutes of Health; National Research Foundation; National Research Foundation Singapore; Alex och Eva Wallströms Stiftelse för Vetenskaplig Forskning och Utbildning; Fondation du cancer du sein du Québec; Vetenskapsrådet; Cancer Research UK; Government of Canada; Forskningsrådet om Hälsa, Arbetsliv och Välfärd; National Human Genome Research Institute; Wellcome Trust; Genome Canada; Cancerfonden; AstraZeneca","keywords":"Medicine; Breast cancer; Internal medicine; Oncology; Cohort; Cancer; Ovarian cancer; Logistic regression; Population","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005345377,0.0002272639,0.0003045512,0.0007208113,0.0004241845,0.0005055469,0.0002697794,0.0003969025,0.0009760486],"category_scores_gemma":[0.001720294,0.000266545,0.0002772231,0.0004459535,0.0003244826,0.0002624004,0.0003371991,0.0002412726,0.0002383478],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001660952,"about_ca_system_score_gemma":0.0001728916,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002995139,"about_ca_topic_score_gemma":0.004053712,"domain_scores_codex":[0.9995494,0.0001182015,0.00005106406,0.0001665446,0.0000754008,0.00003919532],"domain_scores_gemma":[0.9992858,0.000192391,0.0002777602,0.00008515902,0.00007515444,0.00008372946],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001131509,0.00003118912,0.9969789,0.000008300945,0.00003837765,0.0002066298,0.0001217467,0.00003690939,0.0009894994,0.00001307786,0.0001026737,0.001359568],"study_design_scores_gemma":[0.00001283435,0.000122585,0.9975262,0.000005285928,0.00003692941,0.001508544,0.0002067622,0.000171749,0.0001871848,0.00002724098,0.0001892788,0.000005255096],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9996505,0.00008408639,0.00004548853,0.00001086314,0.00000135862,0.000004185769,0.00009821157,0.000002367893,0.0001030155],"genre_scores_gemma":[0.9992869,0.0001035293,0.0001066029,0.00002973291,0.00000838373,0.00001028327,0.0003508308,0.000002888773,0.0001009091],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002995139,"threshold_uncertainty_score":0.005955398,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005606459154471484,"score_gpt":0.2904681217512152,"score_spread":0.2848616625967437,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}