{"id":"W2890429637","doi":"10.3390/molecules23092387","title":"d-Amino Acid Pseudopeptides as Potential Amyloid-Beta Aggregation Inhibitors","year":2018,"lang":"en","type":"article","venue":"Molecules","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Molecular dynamics; Peptide; Umbrella sampling; Neurotoxicity; Amyloid beta; Chemistry; Amino acid; Amyloid (mycology); Biophysics; Biochemistry; Biology; Computational chemistry; Toxicity; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0000694124,0.0001688745,0.0001755653,0.0001242959,0.0001580108,0.00004736528,0.00008321965,0.00007710136,0.0004485693],"category_scores_gemma":[0.00005592813,0.0001374823,0.0001207025,0.000169774,0.0002322754,0.0001117608,0.00006449703,0.00009904578,0.001923354],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005815967,"about_ca_system_score_gemma":0.0001554407,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001114274,"about_ca_topic_score_gemma":0.00001005512,"domain_scores_codex":[0.9986514,0.00004826361,0.0001745767,0.0003031192,0.0004710389,0.0003515552],"domain_scores_gemma":[0.9991195,0.00001149487,0.00005238127,0.0003001801,0.0001820955,0.0003343097],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.006234403,0.005753172,0.1232099,0.0004711548,0.02677096,0.009145541,0.001646921,0.00001031288,0.471294,0.004752325,0.05934856,0.2913628],"study_design_scores_gemma":[0.003155765,0.00178882,0.04937913,0.0001991863,0.0006746446,0.0001854473,0.000183936,0.0002164564,0.9411705,0.0009713381,0.001769449,0.0003053998],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9859169,0.00272428,0.0001365555,0.000738266,0.0001272037,0.0003741192,0.00001627579,0.0001021188,0.009864272],"genre_scores_gemma":[0.9979637,0.00007962157,0.0006145088,0.0003098235,0.0004897231,0.00003051614,0.000109372,0.00003069843,0.000371983],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4698765,"threshold_uncertainty_score":0.9988537,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01531431175682641,"score_gpt":0.2924460543292123,"score_spread":0.2771317425723859,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}