{"id":"W2890430536","doi":"10.1016/j.neuron.2018.08.031","title":"Menin Deficiency Leads to Depressive-like Behaviors in Mice by Modulating Astrocyte-Mediated Neuroinflammation","year":2018,"lang":"en","type":"article","venue":"Neuron","topic":"Tryptophan and brain disorders","field":"Neuroscience","cited_by":245,"is_retracted":false,"has_abstract":false,"ca_institutions":"Royal Ottawa Mental Health Centre; University of Ottawa","funders":"Fundamental Research Funds for the Central Universities; National Key Research and Development Program of China; National Natural Science Foundation of China","keywords":"MEN1; Neuroinflammation; Astrocyte; Inflammation; Downregulation and upregulation; Pathogenesis; Major depressive disorder; Neuroscience; Endocrinology; Psychology; Internal medicine; Medicine; Biology; Central nervous system; Endocrine system; Gene; Genetics; Hormone","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008696943,0.0001953677,0.0001446762,0.0001874631,0.0001554176,0.00006932399,0.0003510575,0.00006818689,0.00005038395],"category_scores_gemma":[0.0006561435,0.00020592,0.00003862362,0.0006620823,0.0001007623,0.000276672,0.0001088458,0.0002072695,0.000269185],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003856243,"about_ca_system_score_gemma":0.00002620886,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004509788,"about_ca_topic_score_gemma":0.00007359963,"domain_scores_codex":[0.9980664,0.0001631584,0.0003101186,0.0006379817,0.0003492243,0.0004730971],"domain_scores_gemma":[0.9993496,0.0001582068,0.0001086128,0.0002323544,0.00002890996,0.0001223049],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003879713,0.00007024634,0.002188014,0.000005048607,1.490158e-7,0.00001285957,0.0003126855,0.0001851846,0.9939061,0.00002299111,0.0008222843,0.002435572],"study_design_scores_gemma":[0.0007592619,0.0003935544,0.03881562,0.00002143045,0.000003593617,0.000009549845,0.00003626192,0.004147492,0.9545917,0.00001867356,0.0009389347,0.0002639387],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972989,0.00001221577,0.0002604561,0.0002930438,0.0003556142,0.0003579245,0.00001274693,0.0001471731,0.00126195],"genre_scores_gemma":[0.9984927,0.000004806082,0.0001108135,0.001085339,0.00004945415,0.00002648408,0.000006701458,0.00003447157,0.0001892944],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03931448,"threshold_uncertainty_score":0.8397175,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01620779017216161,"score_gpt":0.259997437813378,"score_spread":0.2437896476412164,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}