{"id":"W2890458481","doi":"10.1073/pnas.1804525115","title":"Superoxide dismutase activity confers (p)ppGpp-mediated antibiotic tolerance to stationary-phase <i>Pseudomonas aeruginosa</i>","year":2018,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":108,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Concordia University; McGill University Health Centre","funders":"Canadian Institutes of Health Research; Fonds de Recherche du Québec - Santé; Cystic Fibrosis Canada; Government of Canada; Burroughs Wellcome Fund","keywords":"Pseudomonas aeruginosa; Antibiotics; Microbiology; Superoxide dismutase; Multidrug tolerance; Bacteria; Biology; Multiple drug resistance; Pathogen; Oxidative stress; Biochemistry; Biofilm; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001249999,0.0002682288,0.000156953,0.0001416914,0.0001010361,0.0002837838,0.0001753198,0.0001768842,0.001193008],"category_scores_gemma":[0.0002261789,0.0001228892,0.0001748937,0.0001009665,0.0002275724,0.0001253841,0.0002317259,0.0005138909,0.0003426008],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003011786,"about_ca_system_score_gemma":0.0002032308,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000692157,"about_ca_topic_score_gemma":0.0007502979,"domain_scores_codex":[0.9998796,0.00001932979,0.00001445974,0.00002248548,0.00003113653,0.00003303824],"domain_scores_gemma":[0.9997558,0.00005264967,0.00006031463,0.00003241215,0.0000252357,0.00007354096],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004833368,0.00002576503,0.000239548,0.000009416098,0.000001685202,0.00002182675,0.000006058468,0.00001166421,0.9991591,0.00003792239,0.00002436801,0.0004142392],"study_design_scores_gemma":[0.00001697375,0.0002987185,0.006236755,0.000005211497,0.00001015232,0.0003073336,0.00002483714,0.0007239079,0.991293,0.00006070086,0.001018555,0.000003734014],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970973,0.0002922768,0.001380075,0.00009448963,0.00002917417,0.00001059327,0.0002226451,0.00006399766,0.0008095781],"genre_scores_gemma":[0.9967754,0.0001655023,0.001011804,0.00003281247,0.00001062611,0.00001098636,0.000604035,0.00002265389,0.001366237],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001193008,"threshold_uncertainty_score":0.003991067,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02413862946564517,"score_gpt":0.3169971513126152,"score_spread":0.2928585218469701,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}