{"id":"W2890458481","doi":"10.1073/pnas.1804525115","title":"Superoxide dismutase activity confers (p)ppGpp-mediated antibiotic tolerance to stationary-phase <i>Pseudomonas aeruginosa</i>","year":2018,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":108,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Concordia University; McGill University Health Centre","funders":"Canadian Institutes of Health Research; Fonds de Recherche du Québec - Santé; Cystic Fibrosis Canada; Government of Canada; Burroughs Wellcome Fund","keywords":"Pseudomonas aeruginosa; Antibiotics; Microbiology; Superoxide dismutase; Multidrug tolerance; Bacteria; Biology; Multiple drug resistance; Pathogen; Oxidative stress; Biochemistry; Biofilm; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006237781,0.00013343,0.0001633723,0.00008352514,0.0001842595,0.0000267758,0.0006898088,0.0001043123,0.00001286317],"category_scores_gemma":[0.0007205651,0.0001005817,0.00006741345,0.0004854491,0.001349488,0.00004646898,0.0001646882,0.00008418071,0.000005299627],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002179858,"about_ca_system_score_gemma":0.00008205639,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007579324,"about_ca_topic_score_gemma":5.122199e-7,"domain_scores_codex":[0.9984365,0.00001225183,0.0002800969,0.0003803788,0.0006757215,0.0002150603],"domain_scores_gemma":[0.9991424,0.00004656336,0.0002828561,0.00002194466,0.0004341697,0.00007202934],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001435803,0.00009167683,0.01018378,0.00002837588,0.00001550194,1.362032e-8,0.0000574308,0.00001292772,0.9859973,0.00138362,0.001860176,0.0002256527],"study_design_scores_gemma":[0.0003628924,0.0002319689,0.07827929,0.00005837951,0.000008261452,0.000005195403,0.00008178576,0.0001830315,0.9191629,0.0005385253,0.0009667255,0.0001209805],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962906,0.00003458562,0.00002313052,0.001578377,0.00004475282,0.0002455583,0.0001255557,0.000007634027,0.001649764],"genre_scores_gemma":[0.9971473,0.00002404377,0.001940351,0.0005957623,0.0001539865,0.000002948558,0.000002271479,0.000007292709,0.0001260715],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06809552,"threshold_uncertainty_score":0.4972244,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02413862946564517,"score_gpt":0.3169971513126152,"score_spread":0.2928585218469701,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}