{"id":"W2890466450","doi":"10.1200/jco.2017.35.15_suppl.9523","title":"Management of gastrointestinal (GI) toxicity associated with nivolumab (NIVO) plus ipilimumab (IPI) or IPI alone in phase II and III trials in advanced melanoma (MEL).","year":2017,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Ipilimumab; Internal medicine; Nivolumab; Gastroenterology; Adverse effect; Placebo; Immunotherapy; Cancer; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001307275,0.000268542,0.0004229707,0.0002305047,0.0002353179,0.0003426199,0.0002768156,0.0002910255,0.001164356],"category_scores_gemma":[0.000806394,0.0001077276,0.000430576,0.0002707689,0.0002042888,0.0002461986,0.0002161342,0.0006419604,0.0002196822],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004927677,"about_ca_system_score_gemma":0.0003789113,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002957727,"about_ca_topic_score_gemma":0.001361202,"domain_scores_codex":[0.9996758,0.0001913524,0.00003235172,0.00003172897,0.00003197166,0.00003695348],"domain_scores_gemma":[0.9995949,0.0001277307,0.0001548848,0.00001523079,0.00001703392,0.00009026831],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.09197977,0.00631422,0.1683798,0.003044672,0.001160342,0.002217278,0.0005193948,0.006628166,0.06980842,0.0003528789,0.01051718,0.6390778],"study_design_scores_gemma":[0.05124912,0.3713552,0.5008789,0.0005079029,0.001606129,0.0119782,0.0002616954,0.008088632,0.02693831,0.0004933992,0.02659068,0.00005187475],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9852196,0.01085324,0.0005780751,0.0003481021,0.00002641329,0.0003971919,0.0002808493,0.00003779771,0.002258748],"genre_scores_gemma":[0.9952847,0.002262899,0.000885414,0.0002565706,0.00005421082,0.0002321404,0.0005193041,0.000007153846,0.0004975898],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001307275,"threshold_uncertainty_score":0.006913662,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1422902508147004,"score_gpt":0.4783152062342483,"score_spread":0.3360249554195479,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}