{"id":"W2890480825","doi":"10.1016/j.ejmech.2018.09.049","title":"Design, synthesis and anti-mycobacterial activity evaluation of benzofuran-isatin hybrids","year":2018,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":72,"is_retracted":false,"has_abstract":false,"ca_institutions":"TRIUMF","funders":"Natural Science Foundation of Jiangsu Province; China Postdoctoral Science Foundation","keywords":"Benzofuran; Cytotoxicity; Vero cell; Chemistry; Mycobacterium tuberculosis; Ethambutol; Rifampicin; Isatin; Isoniazid; In vivo; In vitro; Microbiology; Tuberculosis; Pharmacology; Stereochemistry; Antibiotics; Biochemistry; Biology; Medicine; Organic chemistry; Biotechnology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002404362,0.0001139144,0.0001868892,0.0000215995,0.00004029314,0.00001079503,0.0001534278,0.00003853154,0.00009178013],"category_scores_gemma":[0.0002447177,0.00009762381,0.00005849954,0.00003788155,0.0001281191,0.000005057482,0.00004472988,0.00009727979,9.056938e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001756306,"about_ca_system_score_gemma":0.0001511831,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000151409,"about_ca_topic_score_gemma":2.620685e-7,"domain_scores_codex":[0.998848,0.0002589344,0.0002784886,0.0001424473,0.0003546787,0.000117489],"domain_scores_gemma":[0.9989555,0.00002141484,0.00036751,0.0001618111,0.0003984171,0.00009537984],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000386809,0.00003322047,0.00004297722,0.00002557073,0.00008002087,0.000007058003,0.00006528374,0.000005684534,0.9569303,5.004605e-7,0.0001808787,0.04224173],"study_design_scores_gemma":[0.001077189,0.0005089229,0.001400988,0.0001003252,0.0001945735,0.0002130018,0.00007523039,0.0000771956,0.9949121,0.00001728173,0.001329964,0.0000932421],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.992312,0.000497811,0.005796198,0.00009582088,0.0002276958,0.00005476989,0.000005729503,0.000001856007,0.001008174],"genre_scores_gemma":[0.99773,0.0001881428,0.0006168028,0.00004194121,0.001377741,7.557043e-7,0.000002186599,0.00001811301,0.00002438498],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04214849,"threshold_uncertainty_score":0.3980983,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0345980448756822,"score_gpt":0.2791004757944998,"score_spread":0.2445024309188176,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}