{"id":"W2890480825","doi":"10.1016/j.ejmech.2018.09.049","title":"Design, synthesis and anti-mycobacterial activity evaluation of benzofuran-isatin hybrids","year":2018,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":72,"is_retracted":false,"has_abstract":false,"ca_institutions":"TRIUMF","funders":"Natural Science Foundation of Jiangsu Province; China Postdoctoral Science Foundation","keywords":"Benzofuran; Cytotoxicity; Vero cell; Chemistry; Mycobacterium tuberculosis; Ethambutol; Rifampicin; Isatin; Isoniazid; In vivo; In vitro; Microbiology; Tuberculosis; Pharmacology; Stereochemistry; Antibiotics; Biochemistry; Biology; Medicine; Organic chemistry; Biotechnology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001698436,0.0002125772,0.0001635522,0.0002047334,0.0001228467,0.0002073508,0.000248334,0.0002769,0.001085451],"category_scores_gemma":[0.0001352601,0.000114004,0.000213454,0.000178722,0.0001065053,0.0002069903,0.0001570834,0.0003612634,0.0002848871],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002943383,"about_ca_system_score_gemma":0.0001277464,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002013886,"about_ca_topic_score_gemma":0.0003962872,"domain_scores_codex":[0.9999223,0.00001167814,0.000004807606,0.00001356806,0.00002001283,0.00002766151],"domain_scores_gemma":[0.9999459,0.000006650838,0.00001970002,0.000004962992,0.00001162374,0.0000111933],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001171285,0.00007784087,0.000125969,0.00006838633,0.00001218761,0.00007158649,0.00003396192,0.0008237202,0.9929537,0.0004717501,0.00009184527,0.005151856],"study_design_scores_gemma":[0.00003866332,0.001254027,0.001115841,0.000006895115,0.00002372941,0.0001407396,0.00001859181,0.0008611697,0.9910913,0.00008582096,0.005352765,0.00001045241],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9884121,0.001265404,0.006089316,0.0001320076,0.00002936489,0.00009327303,0.0002364605,0.00007910765,0.003662941],"genre_scores_gemma":[0.9911118,0.0006097964,0.004554622,0.00007007046,0.000008292764,0.00006496745,0.000344177,0.00001218294,0.003224053],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001085451,"threshold_uncertainty_score":0.003631234,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0345980448756822,"score_gpt":0.2791004757944998,"score_spread":0.2445024309188176,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}