{"id":"W2890488556","doi":"10.1038/s41386-018-0192-8","title":"Antidepressant potential of metabotropic glutamate receptor mGlu2 and mGlu3 negative allosteric modulators","year":2018,"lang":"en","type":"article","venue":"Neuropsychopharmacology","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":16,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institute of Neurological Disorders and Stroke; National Institute of Mental Health; Ontario Ministry of Research and Innovation; Canadian Institutes of Health Research; National Institute on Drug Abuse; Stanley Center for Psychiatric Research, Broad Institute; National Institutes of Health; Medical Research Council; Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Alliance for Research on Schizophrenia and Depression; Richard Tam Foundation; Genome Canada; Eli Lilly and Company; Assurex Health; Broad Institute; Fulbright Canada; AstraZeneca; Bristol-Myers Squibb; Natural Sciences and Engineering Research Council of Canada; Edward N. and Della L. Thome Memorial Foundation; University of Michigan; CHDI Foundation; Agence Nationale de la Recherche; Pharmaceutical Research and Manufacturers of America Foundation; Brain and Behavior Research Foundation","keywords":"Metabotropic glutamate receptor; Metabotropic glutamate receptor 2; Metabotropic glutamate receptor 5; Neuroscience; Allosteric modulator; Glutamate receptor; Antidepressant; Metabotropic receptor; Metabotropic glutamate receptor 7; Pharmacology; Metabotropic glutamate receptor 4; Allosteric regulation; Chemistry; Psychology; Receptor; Medicine; Hippocampus; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001679065,0.0002638866,0.0003907077,0.0001468541,0.0001786671,0.0001939108,0.0003237737,0.000306178,0.002522391],"category_scores_gemma":[0.0001579624,0.00008154413,0.0002420675,0.0001424587,0.0001396089,0.0001965509,0.000139992,0.0004363525,0.0002982049],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001914689,"about_ca_system_score_gemma":0.0002038499,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001005362,"about_ca_topic_score_gemma":0.003619164,"domain_scores_codex":[0.9999377,0.00002201109,0.000004355406,0.00000609016,0.00001018796,0.00001964722],"domain_scores_gemma":[0.9999685,0.0000065479,0.000008487628,0.000003830635,0.000005053445,0.000007616472],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01645536,0.0009691658,0.001727362,0.0009740108,0.0002781131,0.0008091619,0.0001671974,0.0007487457,0.8007115,0.005378017,0.0038902,0.167891],"study_design_scores_gemma":[0.008714003,0.05988155,0.06682811,0.0004347222,0.001851234,0.006784919,0.0005218881,0.01328699,0.734787,0.004047181,0.1027064,0.0001561081],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9593446,0.02783612,0.001315794,0.0007061582,0.0001989118,0.00009456951,0.0002415194,0.00008327476,0.01017905],"genre_scores_gemma":[0.9865361,0.009227102,0.0008613935,0.0003172104,0.0000865158,0.00003971872,0.0001596767,0.000006251812,0.002766105],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002522391,"threshold_uncertainty_score":0.00843817,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03000917433721441,"score_gpt":0.3378305294540175,"score_spread":0.3078213551168031,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}