{"id":"W2890491720","doi":"10.3390/nu10101351","title":"Endogenous Omega (n)-3 Fatty Acids in Fat-1 Mice Attenuated Depression-Like Behavior, Imbalance between Microglial M1 and M2 Phenotypes, and Dysfunction of Neurotrophins Induced by Lipopolysaccharide Administration","year":2018,"lang":"en","type":"article","venue":"Nutrients","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":70,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"Guangdong Science and Technology Department; National Natural Science Foundation of China","keywords":"Endocrinology; Internal medicine; Lipopolysaccharide; Neurotrophic factors; Brain-derived neurotrophic factor; Glial fibrillary acidic protein; Polyunsaturated fatty acid; Neurotrophin; Tumor necrosis factor alpha; Chemistry; Biology; Receptor; Medicine; Biochemistry; Fatty acid; Immunohistochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000256389,0.001050841,0.000707669,0.001156212,0.0003864909,0.000411603,0.0004900579,0.0009210676,0.002982337],"category_scores_gemma":[0.0001625267,0.0005188759,0.0005888944,0.0003422964,0.0007401395,0.0004921178,0.0003463991,0.002480959,0.0005020062],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005444317,"about_ca_system_score_gemma":0.0004843156,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001626522,"about_ca_topic_score_gemma":0.003285588,"domain_scores_codex":[0.9997026,0.00003122343,0.00004432161,0.0000771322,0.00005398476,0.00009071491],"domain_scores_gemma":[0.9994664,0.00002885187,0.0002002415,0.0000374812,0.00005254825,0.00021449],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003478865,0.000536616,0.0003360481,0.00009504365,0.00002218128,0.0001017989,0.0000678492,0.00007009816,0.9934592,0.0001322503,0.0001015774,0.001598639],"study_design_scores_gemma":[0.0007594556,0.008180705,0.01436268,0.0001024525,0.0001793229,0.0004200957,0.0003117644,0.001492491,0.9690396,0.0003715926,0.004740608,0.00003929892],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946578,0.000835845,0.001645051,0.0003471657,0.00009134736,0.00008092589,0.001504152,0.0001682864,0.0006694723],"genre_scores_gemma":[0.9776877,0.001706421,0.005279336,0.0003612491,0.00005560239,0.0005188793,0.001856202,0.0001353306,0.01239933],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002982337,"threshold_uncertainty_score":0.009976923,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0384735332770858,"score_gpt":0.2661003788340184,"score_spread":0.2276268455569326,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}