{"id":"W2890491720","doi":"10.3390/nu10101351","title":"Endogenous Omega (n)-3 Fatty Acids in Fat-1 Mice Attenuated Depression-Like Behavior, Imbalance between Microglial M1 and M2 Phenotypes, and Dysfunction of Neurotrophins Induced by Lipopolysaccharide Administration","year":2018,"lang":"en","type":"article","venue":"Nutrients","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":70,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"Guangdong Science and Technology Department; National Natural Science Foundation of China","keywords":"Endocrinology; Internal medicine; Lipopolysaccharide; Neurotrophic factors; Brain-derived neurotrophic factor; Glial fibrillary acidic protein; Polyunsaturated fatty acid; Neurotrophin; Tumor necrosis factor alpha; Chemistry; Biology; Receptor; Medicine; Biochemistry; Fatty acid; Immunohistochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001106179,0.0002331189,0.0002542711,0.00018184,0.0002203006,0.00007752037,0.0001741596,0.0001367042,0.0000129789],"category_scores_gemma":[0.000164255,0.0002414584,0.00002972404,0.0002928294,0.0001319736,0.0003513692,0.00009331292,0.0002263874,0.00001231774],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002775295,"about_ca_system_score_gemma":0.00004015436,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003387704,"about_ca_topic_score_gemma":0.00002016728,"domain_scores_codex":[0.9979925,0.0002046043,0.0004900579,0.0006692818,0.0003609913,0.0002825844],"domain_scores_gemma":[0.9991419,0.00008495287,0.0002822115,0.0002587373,0.00008679993,0.0001454442],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002246182,0.0001525898,0.0252655,0.00001413075,0.000001906174,0.00001436566,0.0001367392,3.126075e-7,0.9725896,0.00005268877,0.00003299655,0.001514571],"study_design_scores_gemma":[0.001664661,0.0005213541,0.020912,0.00001907065,0.00002310571,0.00004345421,0.00001201376,0.0001306733,0.9762495,0.00005038359,0.0001889088,0.0001848752],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982439,0.00002281761,0.0002774981,0.000100179,0.0005080444,0.0006176175,0.0001254032,0.00007139065,0.00003310684],"genre_scores_gemma":[0.9991995,0.00007724885,0.000116399,0.0003104599,0.0001332435,0.00004067524,0.00002932646,0.00002985728,0.00006327805],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004353498,"threshold_uncertainty_score":0.9846387,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0384735332770858,"score_gpt":0.2661003788340184,"score_spread":0.2276268455569326,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}