{"id":"W2890532892","doi":"10.1016/s0140-6736(18)32167-6","title":"Efficacy and safety of ustekinumab, an IL-12 and IL-23 inhibitor, in patients with active systemic lupus erythematosus: results of a multicentre, double-blind, phase 2, randomised, controlled study","year":2018,"lang":"en","type":"article","venue":"The Lancet","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":324,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"Pfizer; Medac; AstraZeneca; Eli Lilly and Company","keywords":"Medicine; Ustekinumab; Internal medicine; Placebo; Psoriatic arthritis; Lupus nephritis; Lupus erythematosus; Gastroenterology; Immunology; Arthritis; Disease; Infliximab; Antibody; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002957745,0.001668976,0.00512762,0.0005356156,0.0005535199,0.001241758,0.001028342,0.002681862,0.00428676],"category_scores_gemma":[0.003173468,0.001204312,0.002593,0.0005729115,0.002134013,0.001736699,0.000446084,0.003081011,0.0006854492],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007911492,"about_ca_system_score_gemma":0.0008895298,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009336477,"about_ca_topic_score_gemma":0.001101029,"domain_scores_codex":[0.9986348,0.000722956,0.0001323573,0.000220184,0.0001278709,0.0001618417],"domain_scores_gemma":[0.9980208,0.0007868208,0.0004300987,0.0001592987,0.0001317608,0.0004713576],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9842805,0.002787922,0.0005937068,0.0005650797,0.0009001672,0.00002854027,0.00004477943,0.0001422749,0.002499914,0.00002952309,0.0002545779,0.007873026],"study_design_scores_gemma":[0.9402138,0.05512384,0.002910017,0.00002672264,0.0008531846,0.00003567542,0.0000190231,0.000183854,0.0003177229,0.0000625663,0.000235564,0.00001795871],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9857801,0.01017254,0.0005321214,0.0004394916,0.0003546187,0.001074263,0.0005393261,0.00008367226,0.001023805],"genre_scores_gemma":[0.9927351,0.003024893,0.0007192404,0.000713262,0.0004301926,0.0008213929,0.0005326053,0.00002113913,0.00100209],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00512762,"threshold_uncertainty_score":0.01564223,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02245406536625792,"score_gpt":0.2700038569858186,"score_spread":0.2475497916195607,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}