{"id":"W2890532892","doi":"10.1016/s0140-6736(18)32167-6","title":"Efficacy and safety of ustekinumab, an IL-12 and IL-23 inhibitor, in patients with active systemic lupus erythematosus: results of a multicentre, double-blind, phase 2, randomised, controlled study","year":2018,"lang":"en","type":"article","venue":"The Lancet","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":324,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"Pfizer; Medac; AstraZeneca; Eli Lilly and Company","keywords":"Medicine; Ustekinumab; Internal medicine; Placebo; Psoriatic arthritis; Lupus nephritis; Lupus erythematosus; Gastroenterology; Immunology; Arthritis; Disease; Infliximab; Antibody; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005476771,0.0002115699,0.0010462,0.00009284114,0.00009789896,0.000008695249,0.0001518832,0.0001106182,0.000007423963],"category_scores_gemma":[0.00007572579,0.0001182651,0.00003859596,0.0001135867,0.0002732877,0.00008427667,0.00005446617,0.0001046503,0.000004421959],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002084366,"about_ca_system_score_gemma":0.00002986106,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008710304,"about_ca_topic_score_gemma":0.0002240893,"domain_scores_codex":[0.9983422,0.0005608434,0.0005004756,0.0002884569,0.00006219456,0.0002458384],"domain_scores_gemma":[0.9985646,0.000472669,0.0004079373,0.0004139424,0.000115881,0.00002498496],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9244752,0.002060516,0.0552608,0.00003845755,0.0008953515,0.00000317408,0.01191329,0.000001843683,0.002410968,0.00001007995,0.00003626569,0.002894093],"study_design_scores_gemma":[0.9567177,0.002983811,0.03193567,0.0001868295,0.000478127,0.00002025706,0.002109554,0.000006310741,0.005389015,0.000003554411,0.00003627376,0.0001329083],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952576,0.0003672255,0.000002478719,0.00001707928,0.0001905841,0.003675763,0.0003491929,0.00001691979,0.0001231785],"genre_scores_gemma":[0.9996244,0.00005600635,0.00001476471,0.000009925766,0.00005844066,0.0000806694,0.00007357748,0.00001317373,0.00006899892],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03224252,"threshold_uncertainty_score":0.4822709,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02245406536625792,"score_gpt":0.2700038569858186,"score_spread":0.2475497916195607,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}