{"id":"W2890533887","doi":"10.1038/s41598-018-31773-z","title":"Misfolded SOD1 pathology in sporadic Amyotrophic Lateral Sclerosis","year":2018,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":152,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Université Laval; Hôpital de l'Enfant-Jésus","funders":"Kempestiftelserna; Vetenskapsrådet; Knut och Alice Wallenbergs Stiftelse; Fonds de Recherche du Québec - Santé; W. Garfield Weston Foundation; Västerbotten Läns Landsting; Torsten Söderbergs Stiftelse; Kempe Foundation; Weston Brain Institute; ALS Society of Canada","keywords":"SOD1; Amyotrophic lateral sclerosis; Pathological; Pathology; Medicine; Spinal cord; Superoxide dismutase; Disease; Biology; Neuroscience; Internal medicine; Oxidative stress","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.00193127,0.0002403193,0.0004847998,0.0005971884,0.0002763321,0.0001730291,0.0001992693,0.0002091171,0.001743531],"category_scores_gemma":[0.0002930092,0.0001959241,0.0001508252,0.00134924,0.001345052,0.0002128694,0.0001850345,0.0003770866,0.0005133008],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002405222,"about_ca_system_score_gemma":0.0003364859,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001837214,"about_ca_topic_score_gemma":0.0001043249,"domain_scores_codex":[0.9958995,0.0001259079,0.0008207904,0.001254547,0.0009627105,0.0009365382],"domain_scores_gemma":[0.9976262,0.00002482705,0.0002071822,0.001395696,0.0003597886,0.0003862585],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001994023,0.0003716518,0.2717182,0.00006230739,0.00003198869,0.009150885,0.0008748391,0.000004364997,0.695159,0.00005930039,0.01607745,0.006290602],"study_design_scores_gemma":[0.001234073,0.0004283105,0.9602793,0.0003139427,0.00003135687,0.002066586,0.00003311086,0.0003168388,0.01924797,0.004080036,0.01163807,0.0003304445],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9918749,0.0001577318,0.00001569267,0.001462519,0.003629259,0.0006086641,0.000001805682,0.0001155187,0.002133934],"genre_scores_gemma":[0.9914936,0.00002323633,0.0006409273,0.0002429751,0.0003716543,0.00004222037,0.00004916647,0.00004020171,0.007095957],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.688561,"threshold_uncertainty_score":0.999169,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0410843591448424,"score_gpt":0.2961511775089015,"score_spread":0.2550668183640591,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}