{"id":"W2890533887","doi":"10.1038/s41598-018-31773-z","title":"Misfolded SOD1 pathology in sporadic Amyotrophic Lateral Sclerosis","year":2018,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":152,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Université Laval; Hôpital de l'Enfant-Jésus","funders":"Kempestiftelserna; Vetenskapsrådet; Knut och Alice Wallenbergs Stiftelse; Fonds de Recherche du Québec - Santé; W. Garfield Weston Foundation; Västerbotten Läns Landsting; Torsten Söderbergs Stiftelse; Kempe Foundation; Weston Brain Institute; ALS Society of Canada","keywords":"SOD1; Amyotrophic lateral sclerosis; Pathological; Pathology; Medicine; Spinal cord; Superoxide dismutase; Disease; Biology; Neuroscience; Internal medicine; Oxidative stress","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000847548,0.0003100114,0.0002169241,0.001348517,0.0003037656,0.0002524658,0.0001500217,0.0002715059,0.0008109184],"category_scores_gemma":[0.0005205587,0.0003151222,0.0001282971,0.0002405465,0.0006731029,0.0002148115,0.0004269129,0.0001645819,0.0001792582],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000140202,"about_ca_system_score_gemma":0.0001197497,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002512388,"about_ca_topic_score_gemma":0.0006755257,"domain_scores_codex":[0.9996877,0.00007870282,0.00006600068,0.00007746041,0.00006622115,0.00002390097],"domain_scores_gemma":[0.9996212,0.0000670481,0.0001449885,0.00006225669,0.00005135901,0.00005319154],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008419128,0.0000549691,0.04757468,0.0001577339,0.00006023734,0.001321966,0.0003963537,0.0001059285,0.9454081,0.0000991957,0.00006537174,0.003913688],"study_design_scores_gemma":[0.0001058264,0.001834996,0.7336609,0.00005248841,0.0002013781,0.01512947,0.0006292089,0.000763325,0.2451546,0.0007661358,0.001675869,0.00002568188],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988647,0.0004243126,0.0004007488,0.00001111766,0.00000480991,0.000007499775,0.00003489085,0.00001368346,0.000238302],"genre_scores_gemma":[0.9982844,0.000326058,0.0009916525,0.00001763946,0.000006977496,0.00001550674,0.00009134007,0.000007368089,0.0002590355],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001348517,"threshold_uncertainty_score":0.004482329,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0410843591448424,"score_gpt":0.2961511775089015,"score_spread":0.2550668183640591,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}