{"id":"W2890591443","doi":"10.1101/414250","title":"Structural basis for recruitment of DAPK1 to the KLHL20 E3 ligase","year":2018,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Novartis Pharma; Ontario Ministry of Economic Development and Innovation; Medical Research Council; European Federation of Pharmaceutical Industries and Associations; Merck KGaA; Ministero dello Sviluppo Economico; Fundação de Amparo à Pesquisa do Estado de São Paulo; Diamond Light Source; Genome Canada; Pfizer","keywords":"Ubiquitin ligase; Cullin; DNA ligase; Ubiquitin; Neddylation; Biology; Subfamily; Cell biology; Lipid-anchored protein; Salt bridge; Biochemistry; Chemistry; Autophagy; Enzyme; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001155168,0.000238556,0.0002676364,0.0001183835,0.0003487904,0.0003930535,0.0004167516,0.0003688009,0.002879509],"category_scores_gemma":[0.0001901921,0.0001640723,0.0002033005,0.00008803077,0.0001948055,0.0001674302,0.0003383902,0.0004433391,0.0007687074],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008695443,"about_ca_system_score_gemma":0.0004071021,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009629279,"about_ca_topic_score_gemma":0.001099409,"domain_scores_codex":[0.9999142,0.000009788112,0.000006021787,0.00002120886,0.00002361228,0.00002513133],"domain_scores_gemma":[0.9999087,0.0000100475,0.0000211489,0.000005329319,0.00001134052,0.00004354858],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008511524,0.0002253426,0.00876258,0.0002323869,0.00004601157,0.002430654,0.0001446323,0.009884413,0.9644132,0.003769323,0.002742398,0.006497969],"study_design_scores_gemma":[0.0004123804,0.0006516764,0.03750095,0.00005237958,0.00006745547,0.002911268,0.0004413195,0.1144897,0.8199531,0.004783049,0.0186648,0.00007190787],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926503,0.000521534,0.003435733,0.0003604095,0.00004808852,0.00002195784,0.0002508555,0.0002087216,0.002502521],"genre_scores_gemma":[0.9973677,0.0001032937,0.001324031,0.00009161336,0.000005139585,0.00000803844,0.0002718038,0.0000110687,0.0008173559],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002879509,"threshold_uncertainty_score":0.009632885,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03814466860758634,"score_gpt":0.2668849138647328,"score_spread":0.2287402452571465,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}