{"id":"W2890598685","doi":"10.1016/j.neo.2018.08.007","title":"Nuclear Factor I Represses the Notch Effector HEY1 in Glioblastoma","year":2018,"lang":"en","type":"article","venue":"Neoplasia","topic":"MicroRNA in disease regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research","keywords":"Notch signaling pathway; Neural stem cell; Gene knockdown; Neurosphere; Stem cell; Biology; Chromatin immunoprecipitation; Nestin; Cancer research; Transcription factor; Cell biology; Molecular biology; Cellular differentiation; Chemistry; Cell culture; Signal transduction; Gene expression; Adult stem cell; Genetics; Promoter","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006210621,0.0002315475,0.0001992135,0.0002240982,0.0001489798,0.0002607512,0.0001229474,0.0001323837,0.0009045618],"category_scores_gemma":[0.00007836216,0.0001025843,0.0001852088,0.0001544517,0.0001692783,0.0001077909,0.0001803022,0.0003359775,0.0003140655],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004032983,"about_ca_system_score_gemma":0.0002420934,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002031341,"about_ca_topic_score_gemma":0.003313344,"domain_scores_codex":[0.9999316,0.000005253289,0.000006201859,0.00001752731,0.00002104503,0.00001834334],"domain_scores_gemma":[0.999943,0.000004410616,0.00002294869,0.000004423059,0.000007862849,0.0000172975],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007780132,0.00001453691,0.0005589006,0.00003755612,0.000006298834,0.00005473772,0.00001563485,0.00004608064,0.9975286,0.0000752036,0.0001185408,0.001466127],"study_design_scores_gemma":[0.0000335676,0.0002552065,0.05013271,0.00001556388,0.00003132113,0.0005631562,0.0001212791,0.001474899,0.9409932,0.0001872647,0.006182652,0.000009190821],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9916215,0.004562111,0.001349709,0.0001555161,0.00003838194,0.00001123179,0.0006651795,0.0001496964,0.001446607],"genre_scores_gemma":[0.9940755,0.001570492,0.0006776571,0.0001062297,0.000008427741,0.00001529132,0.0009460765,0.00002702093,0.002573278],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002031341,"threshold_uncertainty_score":0.00403899,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0059778914460958,"score_gpt":0.2397537662413102,"score_spread":0.2337758747952144,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}