{"id":"W2890632219","doi":"10.1200/jco.2017.35.15_suppl.e16502","title":"Metformin to treat prostate cancer (PCa) and prevent metabolic syndrome associated with androgen deprivation therapy (ADT): Results of a randomized double-blind placebo-controlled study of metformin in non-diabetic men initiating ADT for advanced PCa.","year":2017,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Metabolism, Diabetes, and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital","funders":"","keywords":"Medicine; Metformin; Internal medicine; Endocrinology; Insulin resistance; Hyperinsulinemia; Metabolic syndrome; Insulin; Prostate cancer; Androgen deprivation therapy; Clinical endpoint; Type 2 diabetes; Placebo; Diabetes mellitus; Randomized controlled trial; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002357997,0.001388316,0.003159195,0.0008607095,0.0005813758,0.0009085403,0.0009772908,0.002113384,0.004492083],"category_scores_gemma":[0.001642783,0.0007469318,0.002087878,0.0005891998,0.00111484,0.00104449,0.0004389188,0.002254738,0.0005200999],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006290274,"about_ca_system_score_gemma":0.00115089,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0014115,"about_ca_topic_score_gemma":0.003462333,"domain_scores_codex":[0.9991789,0.0004847551,0.00006996511,0.00009291334,0.00005882311,0.0001146605],"domain_scores_gemma":[0.9987759,0.0002967937,0.0002111253,0.00007759395,0.00008713338,0.0005514588],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9660919,0.01774932,0.0004208244,0.0004831576,0.0006271861,0.00003034335,0.00003258659,0.0001176378,0.002060093,0.00003196399,0.0003093732,0.01204555],"study_design_scores_gemma":[0.8810624,0.1151616,0.002562699,0.00002932425,0.0003456217,0.00001577944,0.00001811825,0.0001458498,0.0003321166,0.00003698818,0.0002779646,0.00001150828],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9851677,0.006682252,0.0005010953,0.0005132576,0.000590954,0.004294422,0.001029334,0.0001089026,0.001112207],"genre_scores_gemma":[0.9855279,0.004701092,0.001373498,0.001220288,0.0007252775,0.002954897,0.001142035,0.0000232445,0.002331678],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004492083,"threshold_uncertainty_score":0.01502746,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06054494848033803,"score_gpt":0.414958900850354,"score_spread":0.3544139523700159,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}