{"id":"W2890662771","doi":"10.1016/j.celrep.2018.08.057","title":"Regulation of S100A8 Stability by RNF5 in Intestinal Epithelial Cells Determines Intestinal Inflammation and Severity of Colitis","year":2018,"lang":"en","type":"article","venue":"Cell Reports","topic":"S100 Proteins and Annexins","field":"Biochemistry, Genetics and Molecular Biology","cited_by":61,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre hospitalier de l'Université Laval","funders":"National Cancer Institute; National Cancer Institute, Cairo University; Japan Society for the Promotion of Science; Arizona State University","keywords":"Colitis; Inflammation; S100A8; Intestinal epithelium; Chemistry; Cell biology; Biology; Epithelium; Immunology; Medicine; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001379831,0.0002761092,0.0001876746,0.0004576956,0.0001314133,0.0002473257,0.0001845386,0.0003228056,0.001471667],"category_scores_gemma":[0.0001213536,0.0001321858,0.0002252108,0.0001403417,0.0002367221,0.0001949547,0.000138566,0.0005320462,0.0002913159],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004082067,"about_ca_system_score_gemma":0.0001461704,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007979368,"about_ca_topic_score_gemma":0.001738974,"domain_scores_codex":[0.999843,0.00002863369,0.00001387713,0.00003428814,0.000034337,0.00004595206],"domain_scores_gemma":[0.9998548,0.00001293522,0.00004945534,0.00001284054,0.00001429861,0.00005561177],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001477135,0.00001706178,0.0004814422,0.0000126734,0.000004090678,0.00002893667,0.000007095052,0.00002643652,0.9979856,0.00006529674,0.00002680453,0.001196848],"study_design_scores_gemma":[0.00001611692,0.0002663555,0.0185204,0.000008412304,0.00001966896,0.0002101637,0.00004581769,0.0007782566,0.9783545,0.00006759279,0.001707114,0.0000056077],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954376,0.001464573,0.001931224,0.0001097059,0.00002132075,0.000007976941,0.0002521933,0.00009353373,0.0006818408],"genre_scores_gemma":[0.9966629,0.0003569608,0.0008083797,0.0000322532,0.000004376805,0.00001097046,0.0002605765,0.00001387791,0.001849713],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001471667,"threshold_uncertainty_score":0.004923224,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007854798164789945,"score_gpt":0.2229209864972487,"score_spread":0.2150661883324587,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}