{"id":"W2890666817","doi":"10.1038/s41467-018-06196-z","title":"Structural determinants of Rab11 activation by the guanine nucleotide exchange factor SH3BP5","year":2018,"lang":"en","type":"article","venue":"Nature Communications","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Victoria","funders":"National Research Council Canada; Western Economic Diversification Canada; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Associazione Italiana per la Ricerca sul Cancro; Government of Canada; Michael Smith Health Research BC; University of Saskatchewan; Canadian Light Source","keywords":"Rab; Guanine nucleotide exchange factor; GTPase; Cell biology; Small GTPase; Biology; Coiled coil; Chemistry; Signal transduction","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007601547,0.00008376638,0.00007727309,0.00001954203,0.0001865226,0.000009260765,0.000553361,0.0001897402,0.00005073771],"category_scores_gemma":[0.00004608286,0.00006271638,0.00005370772,0.00009099116,0.0002017527,0.000006098816,0.00010004,0.0001931975,0.000002675369],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00000770845,"about_ca_system_score_gemma":0.0000204358,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003476921,"about_ca_topic_score_gemma":0.000745701,"domain_scores_codex":[0.9994985,0.00005528278,0.0001463531,0.0001173657,0.00008758189,0.00009489123],"domain_scores_gemma":[0.9987614,0.00001925325,0.0001027977,0.0009468675,0.0001457954,0.00002388123],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002765632,0.0000209957,0.01099412,0.000005885777,0.00001756168,4.033431e-8,0.0002054339,2.109836e-7,0.9848688,0.0001202235,0.001043998,0.002695122],"study_design_scores_gemma":[0.0003473427,0.0001494117,0.09597097,0.00001725388,0.00002527331,0.000003993004,0.00009735213,0.0003577588,0.6824123,0.00004992072,0.2204079,0.0001605234],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964625,0.001745324,0.0003881557,0.0004990136,0.00008814049,0.0001559689,0.00007007759,0.000008842669,0.0005820065],"genre_scores_gemma":[0.9971216,0.0002771327,0.0003275566,0.0001708407,0.00009606106,0.000008510485,0.001782106,0.00001161986,0.0002045467],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3024565,"threshold_uncertainty_score":0.25575,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01930457197882574,"score_gpt":0.2873260551815652,"score_spread":0.2680214832027394,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}