{"id":"W2890683840","doi":"10.1186/s12863-018-0648-1","title":"Epigenetics, heritability and longitudinal analysis","year":2018,"lang":"en","type":"article","venue":"BMC Genetics","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"National Institute of General Medical Sciences; National Heart, Lung, and Blood Institute; National Institutes of Health","keywords":"Heritability; DNA methylation; Epigenetics; Biology; CpG site; Generalized estimating equation; Fenofibrate; Genetics; Epigenome; Methylation; Missing heritability problem; Random effects model; Statistics; Mathematics; Internal medicine; Meta-analysis; Gene; Medicine; Endocrinology; Single-nucleotide polymorphism; Genotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002770023,0.0001736596,0.0001801459,0.00007866944,0.0001287205,0.00004497208,0.0001477385,0.0001600602,0.00005245841],"category_scores_gemma":[0.0000924999,0.0001776787,0.0001119135,0.0002674913,0.0002787904,0.000001738175,0.0001651924,0.00005046065,0.0000127464],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009101175,"about_ca_system_score_gemma":0.00005396648,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002280275,"about_ca_topic_score_gemma":0.000901047,"domain_scores_codex":[0.9987217,0.00008491144,0.0002597451,0.0005156749,0.0001546102,0.000263416],"domain_scores_gemma":[0.9989749,0.00001829621,0.00007893082,0.0005720474,0.0002145783,0.0001412876],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00003023027,0.00004177977,0.8800639,0.00001229348,0.000138922,3.513634e-7,0.00004341923,0.0002198435,0.1162368,0.00003405302,0.00004443196,0.003133975],"study_design_scores_gemma":[0.0002451832,0.0004237771,0.7411425,0.000001847401,0.0002317243,0.000001313678,0.00002861879,0.001234446,0.2464042,0.0003650044,0.009676714,0.0002446271],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9486669,0.004764494,0.04528026,0.00002533007,0.0001343097,0.0001318531,0.00001708728,0.00001195058,0.0009678177],"genre_scores_gemma":[0.9851314,0.0007033282,0.01333133,0.00003564401,0.0004544527,0.000007949159,0.00006075876,0.0000209651,0.0002541559],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1389214,"threshold_uncertainty_score":0.7245527,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02412525500928458,"score_gpt":0.2907275282900705,"score_spread":0.2666022732807859,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}