{"id":"W2890683840","doi":"10.1186/s12863-018-0648-1","title":"Epigenetics, heritability and longitudinal analysis","year":2018,"lang":"en","type":"article","venue":"BMC Genetics","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"National Institute of General Medical Sciences; National Heart, Lung, and Blood Institute; National Institutes of Health","keywords":"Heritability; DNA methylation; Epigenetics; Biology; CpG site; Generalized estimating equation; Fenofibrate; Genetics; Epigenome; Methylation; Missing heritability problem; Random effects model; Statistics; Mathematics; Internal medicine; Meta-analysis; Gene; Medicine; Endocrinology; Single-nucleotide polymorphism; Genotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01239199,0.0003578259,0.0004448559,0.001509114,0.0003667331,0.001079961,0.0005942621,0.0004819126,0.002001376],"category_scores_gemma":[0.02697222,0.000299943,0.0007377807,0.00176718,0.001199083,0.0009032557,0.0008952978,0.000839748,0.0001342014],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007429049,"about_ca_system_score_gemma":0.0006012408,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003887943,"about_ca_topic_score_gemma":0.00223628,"domain_scores_codex":[0.9960731,0.00221846,0.0002134593,0.0009676513,0.0003792415,0.0001479626],"domain_scores_gemma":[0.9746702,0.01821505,0.002756894,0.002778726,0.00136527,0.0002138382],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002872411,0.00006452168,0.7537209,0.0004744624,0.003053476,0.0004430864,0.001211371,0.01256685,0.003415517,0.04996913,0.003525978,0.1712675],"study_design_scores_gemma":[0.00003526181,0.0001783416,0.8477137,0.000328925,0.001164443,0.0006501409,0.0004236911,0.02569803,0.002748054,0.1069622,0.0140058,0.00009140209],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5647808,0.01899347,0.3949071,0.005589503,0.0003980694,0.0001775536,0.005976058,0.0006291682,0.008548318],"genre_scores_gemma":[0.9618228,0.002248643,0.03336324,0.0003280062,0.0002023715,0.0001499415,0.000876588,0.0000934183,0.0009149727],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01239199,"threshold_uncertainty_score":0.06553596,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02412525500928458,"score_gpt":0.2907275282900705,"score_spread":0.2666022732807859,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}