{"id":"W2890764438","doi":"10.1016/j.bone.2018.09.006","title":"Collagen type I degradation fragments act through the collagen receptor LAIR-1 to provide a negative feedback for osteoclast formation","year":2018,"lang":"en","type":"article","venue":"Bone","topic":"Bone Metabolism and Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":false,"ca_institutions":"Montreal Children's Hospital; University of British Columbia; McGill University; Shriners Hospitals for Children - Canada","funders":"Canadian Institutes of Health Research; British Heart Foundation; Réseau de Recherche en Santé Buccodentaire et Osseuse; Faculty of Dentistry, McGill University","keywords":"Osteoclast; Chemistry; Cathepsin K; Type I collagen; Cell biology; Haematopoiesis; Bone resorption; Molecular biology; Receptor; Biochemistry; Endocrinology; Biology; Stem cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001092573,0.0001240407,0.0001116093,0.00001830398,0.0002065039,0.00004790312,0.000125564,0.0000772254,0.0000488761],"category_scores_gemma":[0.0002904541,0.00009268714,0.00005328902,0.0001632355,0.00005800709,0.00001892658,0.00007558922,0.00001376603,0.0001410328],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001946867,"about_ca_system_score_gemma":0.0001068451,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002976083,"about_ca_topic_score_gemma":0.0001573838,"domain_scores_codex":[0.9992412,0.00005222026,0.0001711054,0.0002210331,0.0001208041,0.0001935876],"domain_scores_gemma":[0.9993151,0.0000205688,0.00009405553,0.0002577938,0.0002571826,0.00005523286],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001838976,0.0001186574,0.0001972934,0.00004514947,0.00007789343,3.655527e-7,0.001183201,0.00002143207,0.6106778,0.000211938,0.3759786,0.009648667],"study_design_scores_gemma":[0.0008354907,0.0005263708,0.001012506,0.00001394508,0.00004273334,0.000001829197,0.0004740495,0.00002928793,0.3962536,0.0002468777,0.6004087,0.0001546493],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.990025,0.000384181,0.004319812,0.001101784,0.000361769,0.001510767,0.0002121961,0.00001852807,0.002065931],"genre_scores_gemma":[0.9857302,0.00005198154,0.005472314,0.001642599,0.0007062103,0.0002207991,0.000481195,0.00002720073,0.005667556],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2244301,"threshold_uncertainty_score":0.3779671,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01829191876969471,"score_gpt":0.2744186405241326,"score_spread":0.2561267217544378,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}