{"id":"W2890780539","doi":"10.1080/1028415x.2018.1521088","title":"Cocoa beans improve mitochondrial biogenesis via PPARγ/PGC1α dependent signalling pathway in MPP<sup>+</sup>intoxicated human neuroblastoma cells (SH-SY5Y)","year":2018,"lang":"en","type":"article","venue":"Nutritional Neuroscience","topic":"Biochemical and biochemical processes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"Science and Engineering Research Board; Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada","keywords":"TFAM; FIS1; MFN2; Mitochondrial biogenesis; Tyrosine hydroxylase; Mitochondrion; Cell biology; COCOA BEAN; Biology; Peroxisome proliferator-activated receptor; SH-SY5Y; mitochondrial fusion; Biochemistry; Mitochondrial DNA; Receptor; Neuroblastoma; Cell culture; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008753913,0.0002961239,0.0004552628,0.0003065764,0.0001586305,0.0002739182,0.0001440884,0.0002509376,0.001127233],"category_scores_gemma":[0.00008594573,0.000130288,0.0004151535,0.00019733,0.0001595692,0.000208133,0.0002407813,0.0005494917,0.0002359713],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002113751,"about_ca_system_score_gemma":0.0002038425,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002331643,"about_ca_topic_score_gemma":0.003200424,"domain_scores_codex":[0.9999348,0.000008270296,0.000009041167,0.00001614926,0.00001561634,0.00001607755],"domain_scores_gemma":[0.9999319,0.000006135796,0.00001876637,0.000007865094,0.0000165754,0.00001883173],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008919793,0.00009591967,0.0002543848,0.0001336193,0.00002177794,0.00007309491,0.00002401747,0.0000318956,0.9964039,0.00002369643,0.00008137034,0.00196443],"study_design_scores_gemma":[0.00008670828,0.002913676,0.02357509,0.00003617998,0.0001903068,0.0003339934,0.0001756292,0.0007663471,0.9651356,0.00007949997,0.006693929,0.00001303859],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931332,0.003931843,0.001011348,0.0002068367,0.00008187462,0.00002545119,0.0006366872,0.00009160931,0.0008810674],"genre_scores_gemma":[0.992676,0.001941192,0.001126612,0.0001475009,0.00001608215,0.00003322588,0.0008399911,0.00003000443,0.003189412],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002331643,"threshold_uncertainty_score":0.004636109,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0124759846888343,"score_gpt":0.2375341526397946,"score_spread":0.2250581679509603,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}