{"id":"W2890780539","doi":"10.1080/1028415x.2018.1521088","title":"Cocoa beans improve mitochondrial biogenesis via PPARγ/PGC1α dependent signalling pathway in MPP<sup>+</sup>intoxicated human neuroblastoma cells (SH-SY5Y)","year":2018,"lang":"en","type":"article","venue":"Nutritional Neuroscience","topic":"Biochemical and biochemical processes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"Science and Engineering Research Board; Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada","keywords":"TFAM; FIS1; MFN2; Mitochondrial biogenesis; Tyrosine hydroxylase; Mitochondrion; Cell biology; COCOA BEAN; Biology; Peroxisome proliferator-activated receptor; SH-SY5Y; mitochondrial fusion; Biochemistry; Mitochondrial DNA; Receptor; Neuroblastoma; Cell culture; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001395986,0.0003545848,0.0002490001,0.0001150343,0.0002751599,0.00008693108,0.0007513359,0.0003145532,0.00004983801],"category_scores_gemma":[0.0001249472,0.0003398556,0.000154088,0.0005045061,0.0007795785,0.00002357672,0.0002974996,0.000253164,0.00003397842],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003207299,"about_ca_system_score_gemma":0.00009590233,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002655909,"about_ca_topic_score_gemma":0.00001621754,"domain_scores_codex":[0.997039,0.00008045459,0.0004922595,0.001241884,0.0005071949,0.0006391709],"domain_scores_gemma":[0.998979,0.00003991171,0.0001365864,0.0003407844,0.0002334775,0.0002702151],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001842501,0.000530945,0.00009614393,0.00004280593,0.000004264856,0.00001407165,0.00001147541,0.00004499963,0.9980202,0.00002031518,0.0008119622,0.0002185616],"study_design_scores_gemma":[0.0008907186,0.0007535878,0.00014407,0.00004175124,0.000008398894,0.00002413299,0.00001016354,0.0008115625,0.9921411,0.0003827201,0.004378651,0.0004131256],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966003,0.0001613537,0.001714392,0.00037116,0.0003267648,0.0003622479,0.0002201072,0.000042844,0.0002008536],"genre_scores_gemma":[0.9964789,0.00006180129,0.0004956676,0.001536598,0.001023205,0.00006457398,0.0001315585,0.00003113953,0.0001765119],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005879087,"threshold_uncertainty_score":0.9999053,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0124759846888343,"score_gpt":0.2375341526397946,"score_spread":0.2250581679509603,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}