{"id":"W2890800456","doi":"10.1074/jbc.ra118.003723","title":"K-Ras Lys-42 is crucial for its signaling, cell migration, and invasion","year":2018,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Environmental Health Sciences; National Institute of General Medical Sciences; National Cancer Institute; National Institutes of Health; York University","keywords":"Cell biology; Cell; Signal transduction; Cell migration; Biology; Chemistry; Computational biology; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002989204,0.0001239458,0.0001667508,0.00001720487,0.00009952512,0.00002823482,0.0001240713,0.0002586473,0.0001051256],"category_scores_gemma":[0.000239948,0.00009195093,0.0001265898,0.0000455827,0.0001048457,0.000005859877,0.00005128552,0.00008685288,0.000001919029],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009236423,"about_ca_system_score_gemma":0.00006336263,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":5.950737e-7,"about_ca_topic_score_gemma":5.616074e-7,"domain_scores_codex":[0.9991972,0.00002509285,0.0003313844,0.0001971756,0.0001002671,0.000148919],"domain_scores_gemma":[0.9991011,0.00002109848,0.0002807631,0.00009414458,0.0003853024,0.0001175639],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002169636,0.00004119769,0.0006730128,0.00003149305,0.00001712593,0.000001922138,0.00002209987,0.00000255467,0.9969535,0.000006058382,0.001463968,0.000570103],"study_design_scores_gemma":[0.0006559424,0.0004794843,0.0001952018,0.0000287829,0.00001597968,0.00004603155,0.00003949478,0.00004204655,0.9764758,0.000285629,0.02161119,0.0001244363],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952186,0.001397433,0.002625069,0.0002772412,0.00006000259,0.00009215227,0.00001597363,0.000004304925,0.0003092307],"genre_scores_gemma":[0.9956439,0.0001914606,0.002092383,0.0003937243,0.00136481,0.000004060842,0.00002417951,0.000008011303,0.0002775346],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02047772,"threshold_uncertainty_score":0.374965,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02542476949848051,"score_gpt":0.2645829339586863,"score_spread":0.2391581644602057,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}