{"id":"W2890820440","doi":"10.1016/j.bmc.2018.09.017","title":"Nanomolar binding affinity of quinine-based antimalarial compounds by the cocaine-binding aptamer","year":2018,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":false,"ca_institutions":"York University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Chemistry; Aptamer; Isothermal titration calorimetry; Amodiaquine; Binding site; Quinine; Ligand (biochemistry); Stereochemistry; Chloroquine; Biochemistry; Receptor; Malaria","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005431527,0.0002852709,0.0003274375,0.00003403312,0.0002325579,0.0000220198,0.0004443056,0.000298194,0.00003994621],"category_scores_gemma":[0.0002594946,0.0002067115,0.0001541957,0.0003167258,0.0008962504,0.000004964033,0.0001318768,0.0002284087,0.000005629159],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003951438,"about_ca_system_score_gemma":0.0001654127,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002409688,"about_ca_topic_score_gemma":0.000004792756,"domain_scores_codex":[0.998346,0.00006263018,0.0004173702,0.0004699969,0.0003463787,0.0003575768],"domain_scores_gemma":[0.9987202,0.00004748596,0.0003233634,0.0005764222,0.0002206935,0.0001118073],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000135134,0.00007993218,0.0008826575,0.0000351834,0.00008903438,0.000003029612,0.00001600525,8.628461e-8,0.9907546,0.000002357476,0.007702956,0.0002990331],"study_design_scores_gemma":[0.0006333621,0.0002741742,0.00008612072,0.00007556207,0.0001094595,0.0000414992,0.0002070568,0.00002831065,0.9896051,0.000005273184,0.008689484,0.0002446289],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968142,0.000296231,0.001179464,0.0004573437,0.0001381856,0.0001084091,0.00008100962,0.00005139146,0.0008737479],"genre_scores_gemma":[0.9971648,0.00004534737,0.0009197918,0.0002605025,0.0008547911,0.000003777711,0.0003396786,0.00003351977,0.0003777999],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001149523,"threshold_uncertainty_score":0.8429452,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01062007893039127,"score_gpt":0.2618813788273521,"score_spread":0.2512612998969609,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}