{"id":"W2890953042","doi":"10.1098/rsos.180837","title":"Synthesis of novel ( <i>E</i> )-1-(2-(2-(4(dimethylamino) benzylidene) hydrazinyl)-4-methylthiazol-5-yl)ethanone derivatives as ecto-5′-nucleotidase inhibitors","year":2018,"lang":"en","type":"article","venue":"Royal Society Open Science","topic":"Adenosine and Purinergic Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Canadian Institutes of Health Research; Higher Education Commision, Pakistan; Organisation for the Prohibition of Chemical Weapons","keywords":"Chemistry; 5'-nucleotidase; Enzyme; Stereochemistry; Docking (animal); Thiazole; Biochemistry; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001076103,0.0003243363,0.0002797545,0.0001337196,0.0001163249,0.0001599394,0.0003703644,0.0003281685,0.001421017],"category_scores_gemma":[0.0001105065,0.0001191126,0.0002188731,0.0001706813,0.000112819,0.0002049268,0.0001540262,0.0003479641,0.0005745597],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001891957,"about_ca_system_score_gemma":0.0002122961,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005471723,"about_ca_topic_score_gemma":0.001304814,"domain_scores_codex":[0.9999471,0.000008764144,0.000005919584,0.00001003496,0.00001048171,0.00001765806],"domain_scores_gemma":[0.9999622,0.000004856072,0.0000117097,0.000004056889,0.000007966878,0.000009201014],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001559729,0.00009942408,0.0001471565,0.0004548041,0.00002421694,0.000423876,0.00004892954,0.001042089,0.9857345,0.0008231116,0.0005284582,0.01051755],"study_design_scores_gemma":[0.0001581385,0.001947199,0.002420814,0.0000452608,0.00006037857,0.0009437526,0.00004223009,0.002552116,0.9684829,0.0002185719,0.02308866,0.00003991526],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9270014,0.02249216,0.03080834,0.0004652719,0.0002504539,0.0003712868,0.001739593,0.000419276,0.01645231],"genre_scores_gemma":[0.9710082,0.008361809,0.0135881,0.0001504785,0.00003033101,0.000129464,0.0008323364,0.00002363477,0.005875675],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001421017,"threshold_uncertainty_score":0.004753709,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01485582565400765,"score_gpt":0.2900186088301404,"score_spread":0.2751627831761327,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}