{"id":"W2890953042","doi":"10.1098/rsos.180837","title":"Synthesis of novel ( <i>E</i> )-1-(2-(2-(4(dimethylamino) benzylidene) hydrazinyl)-4-methylthiazol-5-yl)ethanone derivatives as ecto-5′-nucleotidase inhibitors","year":2018,"lang":"en","type":"article","venue":"Royal Society Open Science","topic":"Adenosine and Purinergic Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Canadian Institutes of Health Research; Higher Education Commision, Pakistan; Organisation for the Prohibition of Chemical Weapons","keywords":"Chemistry; 5'-nucleotidase; Enzyme; Stereochemistry; Docking (animal); Thiazole; Biochemistry; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001677769,0.000299335,0.0003612696,0.00005087374,0.0006167351,0.0001756697,0.00205663,0.0001952232,0.0001523316],"category_scores_gemma":[0.0008197525,0.0002750178,0.000234548,0.0007775263,0.001980422,0.00005186165,0.001739584,0.0001598602,0.00003318757],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004149802,"about_ca_system_score_gemma":0.0005903373,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006544749,"about_ca_topic_score_gemma":0.00001376765,"domain_scores_codex":[0.9973168,0.00006850039,0.0004604312,0.0009475616,0.0006143605,0.0005923778],"domain_scores_gemma":[0.9981331,0.0001225358,0.0003043099,0.000719831,0.0004823413,0.0002379322],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005040117,0.0001897692,0.00110371,0.00002109456,0.00006071667,0.000001300796,0.0006135009,0.0001369421,0.9886969,0.0001648314,0.007827436,0.001133361],"study_design_scores_gemma":[0.0005180775,0.0003949006,0.001495726,0.00006771359,0.00003210205,0.000008303908,0.0006721072,0.0006915744,0.9909468,0.00007727816,0.00471851,0.0003769458],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9850024,0.0005106376,0.003390621,0.0003068117,0.0002416566,0.0003656402,0.00002727926,0.00002065121,0.01013433],"genre_scores_gemma":[0.98133,0.00005734522,0.01607049,0.0008105231,0.000419178,0.0000294009,0.00001011017,0.00003329385,0.001239661],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01267987,"threshold_uncertainty_score":0.9999702,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01485582565400765,"score_gpt":0.2900186088301404,"score_spread":0.2751627831761327,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}