{"id":"W2890962223","doi":"10.1016/j.matbio.2018.09.004","title":"Adamts10 inactivation in mice leads to persistence of ocular microfibrils subsequent to reduced fibrillin-2 cleavage","year":2018,"lang":"en","type":"article","venue":"Matrix Biology","topic":"Protease and Inhibitor Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":53,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Eye Institute; Canadian Institutes of Health Research; National Institutes of Health; Marfan Foundation; Knights Templar Eye Foundation; American Heart Association","keywords":"Fibrillin; Microfibril; Ectopia lentis; Pathology; Biology; Medicine; Molecular biology; Marfan syndrome; Internal medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002344549,0.0001512873,0.0002176359,0.0001321655,0.00003849225,0.000007027523,0.0002130734,0.0002248154,0.0000177503],"category_scores_gemma":[0.0001470592,0.0001504025,0.00007487556,0.0002296037,0.00007234987,0.000004780446,0.0001572242,0.00005744024,0.00006434396],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004295019,"about_ca_system_score_gemma":0.00006864329,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001094875,"about_ca_topic_score_gemma":0.00005820818,"domain_scores_codex":[0.9987985,0.0001004873,0.0002910238,0.0004370158,0.00006465741,0.0003083009],"domain_scores_gemma":[0.9993757,0.000009323296,0.00008479438,0.0003165471,0.0001168136,0.00009681613],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00026498,0.00002664324,0.000652484,0.00001403186,0.00001196236,0.000001348166,0.00009755362,0.000004892533,0.9971591,0.0002036627,0.001081966,0.0004813476],"study_design_scores_gemma":[0.0002571704,0.001415753,0.0005082312,0.00003103604,0.00000624595,0.000009133707,0.00006716666,0.000006593348,0.9848729,0.00009609688,0.01255272,0.0001769012],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961586,0.0002812443,0.002016307,0.0004286979,0.0002265044,0.0004012443,0.00002955733,0.00001000536,0.0004478591],"genre_scores_gemma":[0.9955935,0.0000202834,0.003243455,0.00048764,0.0003319527,0.00002485883,0.00006178203,0.00001666916,0.0002198612],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01228617,"threshold_uncertainty_score":0.6133237,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01721255816460494,"score_gpt":0.2847416762224966,"score_spread":0.2675291180578917,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}