{"id":"W2890995777","doi":"10.1038/s41598-018-32366-6","title":"Commensal microbiota induces colonic barrier structure and functions that contribute to homeostasis","year":2018,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":198,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Population Health Research Institute","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Crohn's and Colitis Canada","keywords":"Paracellular transport; Barrier function; Biology; Ussing chamber; Tight junction; Intestinal mucosa; Immune system; Inflammation; Gut flora; Intestinal permeability; Microbiology; Mucin; Homeostasis; Mucus; Innate immune system; Immunology; Epithelium; Cell biology; Permeability (electromagnetism); Medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002326735,0.0002749636,0.0002444851,0.0002633581,0.0001562183,0.0003460815,0.0001255553,0.0002621111,0.0008149546],"category_scores_gemma":[0.0002871836,0.0001429898,0.0002219696,0.0001869955,0.0002847516,0.0001922559,0.0003971018,0.000533906,0.0001574574],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001910737,"about_ca_system_score_gemma":0.0002845264,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002835358,"about_ca_topic_score_gemma":0.0005397342,"domain_scores_codex":[0.999736,0.00006587363,0.00001829835,0.00003402689,0.0000777591,0.00006805082],"domain_scores_gemma":[0.9997626,0.00001259349,0.00006463415,0.00003016979,0.00003158018,0.00009848305],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002006732,0.00003601848,0.001016922,0.00003266174,0.000006001718,0.00006498518,0.00001949788,0.00001791666,0.9969923,0.00005045163,0.00002151061,0.001541144],"study_design_scores_gemma":[0.00004657459,0.002472355,0.2048499,0.00003992179,0.00006485777,0.00146087,0.0002857911,0.000836618,0.7862362,0.0003632698,0.003327238,0.00001638081],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961466,0.001546895,0.001108925,0.0001018039,0.00001993492,0.00001808379,0.00008043547,0.000048209,0.0009291443],"genre_scores_gemma":[0.9974918,0.0006624767,0.001215213,0.00003829935,0.000009278418,0.00001207872,0.00007635703,0.00001182708,0.0004826932],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008149546,"threshold_uncertainty_score":0.002726257,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01166374951731619,"score_gpt":0.2606223060355048,"score_spread":0.2489585565181887,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}