{"id":"W2891038428","doi":"10.1158/2326-6066.cir-18-0309","title":"Antibody-Neutralized Reovirus Is Effective in Oncolytic Virotherapy","year":2018,"lang":"en","type":"article","venue":"Cancer Immunology Research","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":79,"is_retracted":false,"has_abstract":true,"ca_institutions":"Oncolytics Biotech (Canada)","funders":"National Cancer Institute; Cancer Research UK","keywords":"Oncolytic virus; Virotherapy; Antibody; Immune system; Immunotherapy; Immunology; Virology; Neutralizing antibody; Internalization; Medicine; Biology; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001720276,0.0001832939,0.0003273386,0.0001889446,0.0001144444,0.0005356292,0.0001597403,0.0003361734,0.001575443],"category_scores_gemma":[0.0001698628,0.00009186529,0.0001915589,0.00009147568,0.0002282758,0.0001421206,0.0001295367,0.0006284689,0.0003608347],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002863944,"about_ca_system_score_gemma":0.0003487161,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009122695,"about_ca_topic_score_gemma":0.001192605,"domain_scores_codex":[0.9998325,0.00003916109,0.000009604584,0.00002220287,0.00003840511,0.00005805407],"domain_scores_gemma":[0.9999084,0.00002646655,0.00001351899,0.00001574376,0.00001153682,0.00002431228],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006738848,0.0003000154,0.0002466492,0.00005345677,0.00001338279,0.00006405484,0.00002461664,0.0002149602,0.9890732,0.0004224236,0.0002120288,0.008701304],"study_design_scores_gemma":[0.0001568407,0.003504198,0.003948955,0.00001396617,0.0000450254,0.0004320778,0.00002632896,0.001534137,0.9828538,0.0001506458,0.007327299,0.000006680905],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9883397,0.004837895,0.002757898,0.0001412416,0.0001367828,0.00006897103,0.0001034827,0.0001021848,0.003511806],"genre_scores_gemma":[0.9963942,0.0006985877,0.0008643931,0.00003556563,0.00001155065,0.00001444932,0.0001016917,0.00001366586,0.001865917],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001575443,"threshold_uncertainty_score":0.005270362,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04479854680528104,"score_gpt":0.4506432649210024,"score_spread":0.4058447181157214,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}