{"id":"W2891038428","doi":"10.1158/2326-6066.cir-18-0309","title":"Antibody-Neutralized Reovirus Is Effective in Oncolytic Virotherapy","year":2018,"lang":"en","type":"article","venue":"Cancer Immunology Research","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":79,"is_retracted":false,"has_abstract":true,"ca_institutions":"Oncolytics Biotech (Canada)","funders":"National Cancer Institute; Cancer Research UK","keywords":"Oncolytic virus; Virotherapy; Antibody; Immune system; Immunotherapy; Immunology; Virology; Neutralizing antibody; Internalization; Medicine; Biology; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001811782,0.0002401603,0.0003191727,0.0004394148,0.0002660037,0.00004531793,0.0008346436,0.0004413928,0.0008544295],"category_scores_gemma":[0.0001459493,0.0002325169,0.0001075989,0.0008260446,0.001623465,0.000009642108,0.0002971707,0.0007556936,0.000379035],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002637928,"about_ca_system_score_gemma":0.0006376625,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006698977,"about_ca_topic_score_gemma":0.001453951,"domain_scores_codex":[0.9960821,0.001196746,0.0003040429,0.000841936,0.0004034801,0.001171667],"domain_scores_gemma":[0.9982589,0.0001125431,0.00005481597,0.0009604427,0.0005013062,0.0001119901],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01071575,0.0001326539,0.0122078,0.00001383727,0.0002024334,0.00001579499,0.000369383,0.000002608241,0.9516832,0.00002364849,0.001015741,0.02361716],"study_design_scores_gemma":[0.003234842,0.007663902,0.01922274,0.00003931931,0.000003697435,0.00001058872,0.00009459685,0.00003146094,0.922329,0.0002774874,0.04682999,0.0002623471],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9849156,0.009747889,0.00003736976,0.0008184429,0.0002436473,0.00115659,0.00002638855,0.00002061731,0.003033443],"genre_scores_gemma":[0.9885862,0.006829885,0.0000364423,0.0006507875,0.0005474278,0.0007918049,0.00004440133,0.00007221986,0.002440773],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04581425,"threshold_uncertainty_score":0.9481764,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04479854680528104,"score_gpt":0.4506432649210024,"score_spread":0.4058447181157214,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}