{"id":"W2891048467","doi":"10.1016/j.cca.2018.09.017","title":"Quantification of methylcitrate in dried urine spots by liquid chromatography tandem mass spectrometry for the diagnosis of propionic and methylmalonic acidemias","year":2018,"lang":"en","type":"article","venue":"Clinica Chimica Acta","topic":"Metabolism and Genetic Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":false,"ca_institutions":"Children's Hospital of Eastern Ontario; University of Ottawa","funders":"Utah Agricultural Experiment Station","keywords":"Methylmalonic acidemia; Urine; Propionic acidemia; Chemistry; Chromatography; Methylmalonic aciduria; Cobalamin; Methylmalonic acid; Newborn screening; Tandem mass spectrometry; Mass spectrometry; Internal medicine; Medicine; Vitamin B12; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009045712,0.0001558771,0.0003471361,0.00008816502,0.0000516269,0.00000967271,0.0003284279,0.0001825493,0.00002469249],"category_scores_gemma":[0.0006337804,0.0001195725,0.0001537816,0.000285367,0.0004564559,0.000005320975,0.00007280628,0.00009273952,5.65937e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000001979365,"about_ca_system_score_gemma":0.0000712935,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001245195,"about_ca_topic_score_gemma":0.00003597731,"domain_scores_codex":[0.99852,0.0001281292,0.0006178212,0.0004026153,0.0001119341,0.0002195601],"domain_scores_gemma":[0.9986469,0.000284183,0.0003628654,0.00054589,0.0001069046,0.00005326941],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000368658,0.0001621316,0.01078156,0.00005598215,0.0001362607,4.374277e-8,0.00005680065,7.752118e-7,0.986183,0.0001342102,0.001391588,0.0007289587],"study_design_scores_gemma":[0.001252219,0.0008276919,0.05092831,0.00002726788,0.0001078154,0.000001013741,0.00008232873,0.00006008097,0.9357077,0.000463627,0.01038319,0.0001587113],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940989,0.003352847,0.0008364427,0.0008211747,0.0001252068,0.0005877154,0.00006117352,0.000005257967,0.000111269],"genre_scores_gemma":[0.9883254,0.008941874,0.002291456,0.0001278464,0.00008451735,0.0001064049,0.00006573125,0.00002102707,0.00003573755],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05047528,"threshold_uncertainty_score":0.4876024,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0219453676836363,"score_gpt":0.3067789212963161,"score_spread":0.2848335536126798,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}