{"id":"W2891060378","doi":"10.1182/bloodadvances.2018019919","title":"B cells with aberrant activation of Notch1 signaling promote Treg and Th2 cell–dominant T-cell responses via IL-33","year":2018,"lang":"en","type":"article","venue":"Blood Advances","topic":"IL-33, ST2, and ILC Pathways","field":"Immunology and Microbiology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics; Japan Society for the Promotion of Science; Universität Ulm","keywords":"Treg cell; Cell biology; Signal transduction; Cell; T cell; Immunology; Biology; IL-2 receptor; Immune system; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002046846,0.0002285174,0.0003445316,0.00009972967,0.0002441639,0.00001112998,0.0001421878,0.0001504761,0.00003796122],"category_scores_gemma":[0.00003032847,0.0001680501,0.00003894343,0.0001524321,0.0004268391,0.0002248796,0.00004253213,0.0001550796,0.00004009859],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008660716,"about_ca_system_score_gemma":0.00008686248,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004799733,"about_ca_topic_score_gemma":0.00003919008,"domain_scores_codex":[0.998803,0.000140625,0.0002911291,0.0003669305,0.00005825085,0.0003401281],"domain_scores_gemma":[0.999137,0.0001836207,0.0002859652,0.0002309153,0.0001360955,0.000026402],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0010785,0.0003086266,0.0003260291,0.0001198724,0.00005198738,0.000005097153,0.001646933,0.000004636208,0.9934761,0.00002041994,0.00005924523,0.002902566],"study_design_scores_gemma":[0.002175566,0.001870903,0.0002724825,0.000127056,0.00009930911,0.00002548173,0.0004237446,0.000003807956,0.9568972,0.0001053175,0.03776858,0.0002305527],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950055,0.001639038,0.000856292,0.00002696836,0.0002486524,0.0003105502,0.000394399,0.00003739441,0.001481168],"genre_scores_gemma":[0.9962451,0.0003457776,0.001402424,0.00004178939,0.00007471273,0.000015055,0.00002471969,0.00002208764,0.00182829],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03770933,"threshold_uncertainty_score":0.6852883,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007486035408711377,"score_gpt":0.2091745635819196,"score_spread":0.2016885281732082,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}