{"id":"W2891062831","doi":"10.1200/jco.2017.35.15_suppl.tps6090","title":"KEYNOTE-412: Pembrolizumab (pembro) in combination with chemoradiation versus chemoradiation alone in locally advanced head and neck squamous cell carcinoma (LA-HNSCC).","year":2017,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Pembrolizumab; Population; Internal medicine; Oncology; Head and neck squamous-cell carcinoma; Placebo; Chemoradiotherapy; Head and neck cancer; Radiation therapy; Cancer; Surgery; Pathology; Immunotherapy; Alternative medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[{"model":"gemma","categories":[],"domain":null,"study_design":"randomized_trial","genre":"empirical","about_ca_system":false,"about_ca_topic":false,"confidence":"low","status":"direct model label, unvalidated"},{"model":"gpt","categories":[],"domain":null,"study_design":"randomized_trial","genre":"empirical","about_ca_system":false,"about_ca_topic":false,"confidence":"high","status":"direct model label, unvalidated"}],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001199845,0.001060381,0.001659493,0.0004553005,0.000367919,0.001002404,0.0009271941,0.00178224,0.01508155],"category_scores_gemma":[0.001186372,0.0004891267,0.001201183,0.0004324977,0.0006353995,0.001269832,0.0005711782,0.002588767,0.001655447],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009541292,"about_ca_system_score_gemma":0.001066174,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006808229,"about_ca_topic_score_gemma":0.001886877,"domain_scores_codex":[0.9996112,0.0001718232,0.00002897737,0.00006836885,0.00003736485,0.00008229996],"domain_scores_gemma":[0.9995276,0.00008615906,0.0001068849,0.00002109865,0.00002049969,0.0002377721],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9450943,0.01144937,0.0005439907,0.001029907,0.0005112152,0.00005368043,0.00004860819,0.0006540607,0.008215416,0.0002188479,0.002393777,0.02978676],"study_design_scores_gemma":[0.6600903,0.327559,0.005264529,0.0001234746,0.0008351848,0.0001042227,0.00005237568,0.0007376461,0.001715146,0.0003314057,0.0031552,0.00003151894],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9779055,0.005885951,0.0004108239,0.00104684,0.0007628142,0.005374067,0.002079287,0.000160639,0.00637395],"genre_scores_gemma":[0.984125,0.002786984,0.0008511909,0.001336267,0.0003211165,0.003948352,0.001360095,0.00002480855,0.005246116],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01508155,"threshold_uncertainty_score":0.05045283,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04883037949348787,"score_gpt":0.3914537141748603,"score_spread":0.3426233346813724,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}