{"id":"W2891085289","doi":"10.1038/s41467-018-04989-w","title":"Identification of multiple risk loci and regulatory mechanisms influencing susceptibility to multiple myeloma","year":2018,"lang":"en","type":"review","venue":"Nature Communications","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":114,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; Princess Margaret Cancer Centre","funders":"Division of Cancer Epidemiology and Genetics, National Cancer Institute; National Heart, Lung, and Blood Institute; Medical Research Council; Hellenic Health Foundation; Mutuelle Générale de l'Education Nationale; Svenska Läkaresällskapet; Center for Translational Molecular Medicine; Deutsche Krebshilfe; Associazione Italiana per la Ricerca sul Cancro; Vetenskapsrådet; World Cancer Research Fund; Stavros Niarchos Foundation; National Cancer Institute; Knut och Alice Wallenbergs Stiftelse; Karolinska Institutet; Blood Cancer UK; Marcus och Amalia Wallenbergs minnesfond; Institut Gustave-Roussy; European Hematology Association; Stiftelsen för Strategisk Forskning; University of Leeds; Deutsche Forschungsgemeinschaft; National Institutes of Health; Heinz Nixdorf Stiftung; Rosetrees Trust; European Commission; Bundesministerium für Bildung und Forschung; National Institute for Health and Care Research; Queensland University of Technology; University of Cambridge; Wellcome Trust; University of Southern California; Cancer Research UK; Ligue Contre le Cancer; Deutsches Krebsforschungszentrum; National Institute of General Medical Sciences; Deutsches Zentrum für Neurodegenerative Erkrankungen; Australian Prostate Cancer Research; National Cancer Research Institute; Lunds Universitet; Instituto de Salud Carlos III; Amgen; Centre International de Recherche sur le Cancer; Institut National de la Santé et de la Recherche Médicale; Multiple Myeloma Research Foundation; Case Western Reserve University; Cancer Research Institute","keywords":"Genome-wide association study; Epigenetics; Biology; Genetics; Genetic association; Biological pathway; Computational biology; microRNA; Gene expression profiling; Gene; Autophagy; Gene expression; Single-nucleotide polymorphism; Apoptosis; Genotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001125568,0.0004204688,0.001312692,0.0004960162,0.0004079348,0.00004103043,0.0009561271,0.0008687383,0.00001989532],"category_scores_gemma":[0.004757347,0.0003514564,0.0003784125,0.0007356019,0.0003758861,0.0001093746,0.0008617709,0.001535843,0.00008718882],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003879876,"about_ca_system_score_gemma":0.0004015807,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001561837,"about_ca_topic_score_gemma":0.001340201,"domain_scores_codex":[0.9967468,0.000639138,0.001087789,0.0006540759,0.000521555,0.0003506116],"domain_scores_gemma":[0.9919292,0.001263483,0.0007384982,0.004949208,0.0007416481,0.00037794],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001479753,0.0009407147,0.01183574,0.01025735,0.001379996,0.000006420546,0.0006258964,6.68539e-7,0.0009761374,0.0008013059,0.001604639,0.9714231],"study_design_scores_gemma":[0.002859531,0.0005913554,0.0895813,0.01057713,0.003557817,0.00009346601,0.0002729304,0.000868183,0.00124615,0.0004123836,0.8889626,0.0009771776],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.004992621,0.9904476,0.0002108835,0.0001113001,0.00009248391,0.00328462,0.0006608736,0.00009261,0.0001069941],"genre_scores_gemma":[0.2070917,0.7809463,0.01051939,0.00003150856,0.00005642431,0.0003183352,0.0008433009,0.00006133199,0.0001317244],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.970446,"threshold_uncertainty_score":0.9998937,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05148444152847069,"score_gpt":0.3816341722775343,"score_spread":0.3301497307490636,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}