{"id":"W2891110262","doi":"10.1172/jci120401","title":"Ubiquitin ligase RNF8 suppresses Notch signaling to regulate mammary development and tumorigenesis","year":2018,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Tech University; Hôpital Maisonneuve-Rosemont; Princess Margaret Cancer Centre; Jewish General Hospital; University of Toronto; University Health Network","funders":"European Regional Development Fund; University Health Network; University of Toronto; Instituto de Salud Carlos III; Ministerio de Economía y Competitividad; Generalitat de Catalunya","keywords":"Ubiquitin ligase; Notch signaling pathway; Cancer research; Carcinogenesis; Biology; Ubiquitin; Hes3 signaling axis; Signal transduction; DNA repair; Breast cancer; Cell biology; Cancer; Genetics; DNA; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001986303,0.0002713015,0.0002358357,0.0002694632,0.0001183044,0.0003015636,0.0002030338,0.0002916621,0.0009762411],"category_scores_gemma":[0.0001567006,0.0001223691,0.0002204482,0.0001049126,0.0001836623,0.0001352111,0.0001477578,0.0003940531,0.0002977798],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003738817,"about_ca_system_score_gemma":0.0002316104,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005258,"about_ca_topic_score_gemma":0.001180309,"domain_scores_codex":[0.9998391,0.00003265584,0.00001393176,0.00003169115,0.00003655489,0.00004596893],"domain_scores_gemma":[0.9998763,0.00001274144,0.00003509386,0.00001741123,0.00001687577,0.00004164186],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002862035,0.00005234445,0.001028596,0.0000316279,0.00001265702,0.0001327093,0.000007741341,0.00008839991,0.9934683,0.0001921623,0.0001277686,0.004571525],"study_design_scores_gemma":[0.00004179732,0.0003442158,0.01072088,0.000008821642,0.00002769059,0.001630665,0.00003765655,0.001686281,0.9780445,0.0001463425,0.007305508,0.000005762248],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.989908,0.004922019,0.002941298,0.0002344731,0.0000478064,0.00001969206,0.0002699989,0.000146434,0.001510235],"genre_scores_gemma":[0.9964446,0.0005834515,0.0008602148,0.00005082385,0.00000654724,0.000009430687,0.0001861436,0.00001480707,0.001843907],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009762411,"threshold_uncertainty_score":0.003265858,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04687807803313673,"score_gpt":0.3379108979024852,"score_spread":0.2910328198693485,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}