{"id":"W2891227713","doi":"10.1200/jco.2017.35.15_suppl.10502","title":"A high-risk genetic profile for premature menopause (PM) in childhood cancer survivors (CCS) exposed to gonadotoxic therapy: A report from the St. Jude Lifetime Cohort (SJLIFE) and Childhood Cancer Survivor Study (CCSS).","year":2017,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Medicine; Oncology; Single-nucleotide polymorphism; Internal medicine; Cohort; Population; SNP; Odds ratio; Genotype; Genetics; Biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001799732,0.000138469,0.0001539179,0.0003905186,0.0002458303,0.0002231505,0.0001342262,0.0002426776,0.001156208],"category_scores_gemma":[0.0005374069,0.0001303851,0.0001645277,0.000430912,0.0001711872,0.00008345615,0.0001686841,0.0001855439,0.00009152218],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001203598,"about_ca_system_score_gemma":0.0001616231,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00439384,"about_ca_topic_score_gemma":0.007748916,"domain_scores_codex":[0.9998983,0.00002012744,0.000009708693,0.00003352908,0.00002234846,0.00001612155],"domain_scores_gemma":[0.9995713,0.000063746,0.0001820987,0.00003736738,0.00003908002,0.0001064918],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00004466781,0.000006043587,0.9987724,0.000003299013,0.00001583052,0.00006084923,0.00002925526,0.0000127389,0.0006246582,0.000005597464,0.00005191514,0.0003725521],"study_design_scores_gemma":[0.000002297362,0.00002272605,0.9996384,0.000001253855,0.000009556967,0.0001635664,0.00003210332,0.00002530267,0.00004828654,0.000003729354,0.00005208711,6.871396e-7],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9993895,0.00007893314,0.00003054737,0.00001429208,0.000001592908,0.000002841329,0.000393077,0.000001472348,0.0000876894],"genre_scores_gemma":[0.9994254,0.00004735926,0.00005345702,0.00001175936,0.000003459445,0.00000394104,0.0003714801,0.000001100667,0.00008195958],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00439384,"threshold_uncertainty_score":0.008736551,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03653410305298986,"score_gpt":0.3940896106472354,"score_spread":0.3575555075942455,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}