{"id":"W2891267158","doi":"10.1186/s13063-018-2877-z","title":"The Comparative Effectiveness of Innovative Treatments for Cancer (CEIT-Cancer) project: Rationale and design of the database and the collection of evidence available at approval of novel drugs","year":2018,"lang":"en","type":"article","venue":"Trials","topic":"Statistical Methods in Clinical Trials","field":"Mathematics","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada Research Chairs; McMaster University; University of Toronto","funders":"Krebsliga Schweiz; Laura and John Arnold Foundation","keywords":"Medicine; Comparative effectiveness research; Research design; Drug approval; Alternative medicine; Pharmacology; Drug; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.01987272,0.0001340522,0.001134971,0.00003464559,0.0001922241,0.000008566002,0.0001787599,0.00006184486,0.00002776246],"category_scores_gemma":[0.09005672,0.00005566446,0.00007980483,0.0004802592,0.001818459,0.00006202308,0.0001154422,0.00006224685,1.522403e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005567231,"about_ca_system_score_gemma":0.0003403602,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002461496,"about_ca_topic_score_gemma":0.00003171922,"domain_scores_codex":[0.9938412,0.004304273,0.001207946,0.0002249245,0.0003110897,0.0001105359],"domain_scores_gemma":[0.7643983,0.2328264,0.001611918,0.0002652948,0.0008852173,0.00001285058],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.1964441,0.001822376,0.002815753,0.005130662,0.006395226,1.134051e-7,0.01688766,0.00007896388,0.4935317,0.2576423,0.01094471,0.008306385],"study_design_scores_gemma":[0.01576297,0.0009406374,0.0009254896,0.001554519,0.0009349805,6.876589e-7,0.0003097362,0.002696098,0.8738962,0.1028027,0.000059716,0.0001162967],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"methods","genre_scores_codex":[0.4827137,0.00325016,0.4438411,0.0005913661,0.001660563,0.06083584,0.006490872,0.00002222324,0.0005941387],"genre_scores_gemma":[0.4490259,0.001711099,0.5406934,0.00004080022,0.0003567034,0.006603011,0.000005573502,0.00004985472,0.001513675],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.3803644,"threshold_uncertainty_score":0.9176081,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.8860932698132773,"score_gpt":0.6364561263352206,"score_spread":0.2496371434780567,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}