{"id":"W2891276185","doi":"10.1016/j.bmc.2018.09.001","title":"4-(3-Alkyl-2-oxoimidazolidin-1-yl)-N-phenylbenzenesulfonamides as new antimitotic prodrugs activated by cytochrome P450 1A1 in breast cancer cells","year":2018,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":11,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval; Hôpital Saint-François d'Assise","funders":"Canada Foundation for Innovation","keywords":"Chemistry; Prodrug; HaCaT; Stereochemistry; Cytochrome P450; Moiety; Chemical synthesis; Structure–activity relationship; Alkyl; Sulfonamide; In vitro; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001913306,0.0002812924,0.0002911712,0.0002120499,0.0001297341,0.0001693562,0.0002401929,0.0001904431,0.001499934],"category_scores_gemma":[0.00009572531,0.0001276027,0.0001440559,0.0001964398,0.0001083649,0.0001554932,0.0001678962,0.0003201191,0.0004380836],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003334647,"about_ca_system_score_gemma":0.0002892025,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001386795,"about_ca_topic_score_gemma":0.004308174,"domain_scores_codex":[0.9999162,0.00002515303,0.000006453219,0.00001032498,0.00001533485,0.00002647013],"domain_scores_gemma":[0.9999677,0.000005938456,0.000007680566,0.000003350658,0.000006563756,0.000008785513],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005074183,0.0001314811,0.0002958849,0.0001932197,0.00001253524,0.0002056571,0.0001142502,0.0008397588,0.975939,0.00114103,0.000576058,0.02004371],"study_design_scores_gemma":[0.0001926231,0.002537957,0.003529033,0.00002127758,0.00003399305,0.0003638663,0.00006440396,0.002158403,0.9771928,0.00009758106,0.01379566,0.00001236687],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9728214,0.008078681,0.005024927,0.0002064831,0.0001328323,0.0001205286,0.0004322151,0.0003256308,0.01285734],"genre_scores_gemma":[0.9881345,0.003625377,0.00212231,0.00005153627,0.0000158076,0.00004943285,0.0003022439,0.00001878617,0.005680006],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001499934,"threshold_uncertainty_score":0.005017757,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0410626882617693,"score_gpt":0.3872433365228238,"score_spread":0.3461806482610545,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}