{"id":"W2891356992","doi":"10.1016/j.euf.2018.08.022","title":"ODM-204, a Novel Dual Inhibitor of CYP17A1 and Androgen Receptor: Early Results from Phase I Dose Escalation in Men with Castration-resistant Prostate Cancer","year":2018,"lang":"en","type":"article","venue":"European Urology Focus","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Astellas Pharma; Physicians' Services Incorporated Foundation; Ipsen Biopharmaceuticals; Genentech; Bayer; Celgene; Meso Scale Diagnostics; Novartis; Amgen","keywords":"Medicine; Prostate cancer; CYP17A1; Androgen deprivation therapy; Castration; Androgen receptor; Oncology; Internal medicine; Dual (grammatical number); Orchiectomy; Urology; Cancer; Hormone","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003102933,0.0001594191,0.0002501868,0.0001342202,0.0000639414,0.0000170767,0.00005049047,0.00005729614,0.000050043],"category_scores_gemma":[0.00005197597,0.0001155718,0.00002281213,0.0002030753,0.000378013,0.0001013303,0.00004717164,0.0001805432,0.00001867959],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005808007,"about_ca_system_score_gemma":0.0001552682,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001034236,"about_ca_topic_score_gemma":0.0006285115,"domain_scores_codex":[0.9986135,0.0001471424,0.0003567653,0.000406944,0.0002051647,0.0002704733],"domain_scores_gemma":[0.9992909,0.00006505051,0.0001440177,0.0002177323,0.0001535589,0.0001287675],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.1149077,0.00142403,0.06258293,0.00005398644,0.0004833835,0.0008313693,0.01690497,0.00001258356,0.7710091,0.00005281695,0.002073156,0.02966395],"study_design_scores_gemma":[0.1288792,0.02524448,0.6931319,0.000370234,0.0003820925,0.00007422562,0.0004701367,0.0005954646,0.1395921,0.00008454095,0.01060633,0.0005692481],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.992377,0.0007286263,0.00001085,0.001476287,0.00005446015,0.0006139585,0.000565758,0.00002614178,0.004146869],"genre_scores_gemma":[0.9985394,0.0001300919,0.0002964124,0.00004555631,0.0002549169,0.00001994156,0.0001527407,0.00003233783,0.0005285927],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.631417,"threshold_uncertainty_score":0.4712881,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02384032539890793,"score_gpt":0.295741604209543,"score_spread":0.2719012788106351,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}