{"id":"W2891373070","doi":"10.1148/radiol.2018180092","title":"Altered Nucleus Basalis Connectivity Predicts Treatment Response in Mild Cognitive Impairment","year":2018,"lang":"en","type":"article","venue":"Radiology","topic":"Functional Brain Connectivity Studies","field":"Neuroscience","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Mental Health; Northern California Institute for Research and Education; NIHR Newcastle Biomedical Research Centre; Canadian Institutes of Health Research; National Institutes of Health; NIHR Nottingham Biomedical Research Centre; Genentech; IXICO; H. Lundbeck A/S; Servier; Eisai; Parkinson's UK; National Institute on Aging; National Institute for Health and Care Research; F. Hoffmann-La Roche; University of Southern California; Pfizer; BioClinica; Biogen; U.S. Department of Defense; Eli Lilly and Company; Bristol-Myers Squibb; Meso Scale Diagnostics; Alzheimer's Disease Neuroimaging Initiative; Alzheimer's Association","keywords":"Nucleus basalis; Medicine; Dementia; Cognition; Alzheimer's disease; Internal medicine; Cholinergic; Cognitive decline; Effects of sleep deprivation on cognitive performance; Rivastigmine; Neuroscience; Disease; Psychiatry; Cholinergic neuron; Psychology; Donepezil","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.0005105321,0.0002322866,0.0003642289,0.0002055538,0.0001899428,0.00001460332,0.0001369516,0.0001085363,0.000113968],"category_scores_gemma":[0.009101766,0.000205015,0.00007771459,0.0002975827,0.00067054,0.0001167824,0.0001028176,0.000126886,0.0002092424],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004880172,"about_ca_system_score_gemma":0.0001184435,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001439256,"about_ca_topic_score_gemma":0.0002293621,"domain_scores_codex":[0.9969656,0.001401346,0.0002266097,0.0007821142,0.0001462782,0.0004780214],"domain_scores_gemma":[0.9867833,0.012724,0.00008614188,0.0002606578,0.00005770853,0.00008822679],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.1034806,0.00533392,0.1274047,0.00005168121,0.000485905,0.001216025,0.02179481,0.0001325721,0.689015,0.005663401,0.03330929,0.01211211],"study_design_scores_gemma":[0.009587727,0.01786478,0.6900194,0.00006849282,0.00004958465,0.0005176633,0.0004943517,0.001659167,0.2665926,0.002100871,0.01042135,0.000623991],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9927827,0.00004584792,0.0000938885,0.004076377,0.000917307,0.0006093017,0.0001514946,0.000117822,0.001205331],"genre_scores_gemma":[0.9958497,0.00002958932,0.00005671556,0.003314757,0.0003608511,0.0001758959,0.000003480481,0.00002086562,0.0001881039],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5626147,"threshold_uncertainty_score":0.999245,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05162944402766202,"score_gpt":0.3020145284859038,"score_spread":0.2503850844582418,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}