{"id":"W2891373070","doi":"10.1148/radiol.2018180092","title":"Altered Nucleus Basalis Connectivity Predicts Treatment Response in Mild Cognitive Impairment","year":2018,"lang":"en","type":"article","venue":"Radiology","topic":"Functional Brain Connectivity Studies","field":"Neuroscience","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Mental Health; Northern California Institute for Research and Education; NIHR Newcastle Biomedical Research Centre; Canadian Institutes of Health Research; National Institutes of Health; NIHR Nottingham Biomedical Research Centre; Genentech; IXICO; H. Lundbeck A/S; Servier; Eisai; Parkinson's UK; National Institute on Aging; National Institute for Health and Care Research; F. Hoffmann-La Roche; University of Southern California; Pfizer; BioClinica; Biogen; U.S. Department of Defense; Eli Lilly and Company; Bristol-Myers Squibb; Meso Scale Diagnostics; Alzheimer's Disease Neuroimaging Initiative; Alzheimer's Association","keywords":"Nucleus basalis; Medicine; Dementia; Cognition; Alzheimer's disease; Internal medicine; Cholinergic; Cognitive decline; Effects of sleep deprivation on cognitive performance; Rivastigmine; Neuroscience; Disease; Psychiatry; Cholinergic neuron; Psychology; Donepezil","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003405376,0.0003107124,0.0004370995,0.0004590011,0.0002683687,0.0003430458,0.0002435698,0.0004073624,0.0008474753],"category_scores_gemma":[0.00142555,0.00009067616,0.0002058558,0.0002616644,0.0002688509,0.0002261601,0.0002241084,0.0003015176,0.00009367138],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005949816,"about_ca_system_score_gemma":0.0002479742,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.008283192,"about_ca_topic_score_gemma":0.01611745,"domain_scores_codex":[0.9998658,0.00002829299,0.00001265329,0.00003982489,0.00002937534,0.00002415926],"domain_scores_gemma":[0.9994407,0.00007853337,0.0003089585,0.00002496172,0.00005313894,0.000093639],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003207872,0.000273928,0.9715006,0.00006219262,0.0002421024,0.0003217451,0.0001765368,0.0004991562,0.006144321,0.00006402502,0.0003057225,0.01720187],"study_design_scores_gemma":[0.00001285269,0.0001735183,0.9990772,0.000004625658,0.00001915964,0.0001346779,0.00003214168,0.0002730807,0.0001605769,0.00005347597,0.00005633481,0.000002326868],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984541,0.0005046538,0.00008559658,0.00006306112,0.000004310954,0.00001581989,0.000156073,0.000005636852,0.0007108169],"genre_scores_gemma":[0.9995539,0.00007865146,0.00008014622,0.00002191878,0.000007243132,0.000006789319,0.0001422622,7.845892e-7,0.0001082453],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008283192,"threshold_uncertainty_score":0.01646996,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05162944402766202,"score_gpt":0.3020145284859038,"score_spread":0.2503850844582418,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}