{"id":"W2891374857","doi":"10.1101/gad.317073.118","title":"DNA polymerase ε-dependent modulation of the pausing property of the CMG helicase at the barrier","year":2018,"lang":"en","type":"article","venue":"Genes & Development","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics; Japan Society for the Promotion of Science; Toyo University; National Institute of Genetics; Ministry of Education, Culture, Sports, Science and Technology","keywords":"Biology; Replisome; Helicase; Polymerase; Repressor lexA; Cell biology; DNA polymerase; Genetics; DNA; DNA replication; Molecular biology; Biophysics; Circular bacterial chromosome; Gene; Repressor; Transcription factor; RNA","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000103484,0.00024187,0.0001167542,0.00009803469,0.00006669248,0.0003043375,0.0001659728,0.000164499,0.0007727709],"category_scores_gemma":[0.0001617635,0.0001319361,0.0001168291,0.0000667087,0.0002409246,0.0001717334,0.0001840155,0.0004194067,0.0002457802],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002202094,"about_ca_system_score_gemma":0.0001198646,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003567063,"about_ca_topic_score_gemma":0.0004036279,"domain_scores_codex":[0.9999079,0.00001665203,0.000007086307,0.00002684189,0.00001933332,0.00002231815],"domain_scores_gemma":[0.9999294,0.00002005095,0.00001900808,0.00001115093,0.000005723552,0.00001467199],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003110089,0.000005032164,0.00009631248,0.00001081708,0.000001596715,0.00001151472,0.000005866225,0.00001725609,0.9993449,0.00005167956,0.000004818532,0.000419235],"study_design_scores_gemma":[0.000003952729,0.00002920471,0.001291047,0.000001872373,0.000002786633,0.00004786182,0.000007634848,0.0003745208,0.9977907,0.0000273179,0.0004215455,0.000001714774],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966833,0.0008763588,0.00171565,0.00004531602,0.00001447777,0.000008110672,0.00007459246,0.00002827738,0.0005537546],"genre_scores_gemma":[0.9984054,0.0002701284,0.0006778842,0.00001501166,0.000003405275,0.000005414449,0.00008631664,0.00001120026,0.0005251789],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007727709,"threshold_uncertainty_score":0.002585173,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01102501926040944,"score_gpt":0.2231704983396074,"score_spread":0.212145479079198,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}