{"id":"W2891407926","doi":"10.1210/en.2018-00705","title":"Scaffold Proteins: From Coordinating Signaling Pathways to Metabolic Regulation","year":2018,"lang":"en","type":"review","venue":"Endocrinology","topic":"14-3-3 protein interactions","field":"Biochemistry, Genetics and Molecular Biology","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier de l’Université de Montréal","funders":"Fonds de Recherche du Québec - Santé; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Banting Research Foundation","keywords":"Scaffold protein; Signal transduction; Scaffold; Endocrinology; Metabolic pathway; Cell biology; Internal medicine; Chemistry; Biology; Metabolism; Medicine; Biomedical engineering","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003831561,0.0008254295,0.001044609,0.00204201,0.0004233235,0.001342961,0.000789805,0.001162264,0.002901382],"category_scores_gemma":[0.000357609,0.0002954381,0.0004421205,0.00150402,0.0007057646,0.001403112,0.0009255872,0.001571462,0.002495046],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000810565,"about_ca_system_score_gemma":0.001003667,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000650451,"about_ca_topic_score_gemma":0.0009765755,"domain_scores_codex":[0.9998308,0.00002543422,0.00002340594,0.00003378958,0.00005775439,0.00002872575],"domain_scores_gemma":[0.9998623,0.00004490138,0.00002384328,0.000006259505,0.00003852989,0.00002418903],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001484111,0.00007129966,0.0004884519,0.0151756,0.0001410456,0.0007810848,0.0001877045,0.0006551982,0.01527887,0.01874355,0.0331336,0.9151952],"study_design_scores_gemma":[0.000007422545,0.00003702612,0.0004885059,0.0008006612,0.00003896509,0.001186737,0.00005085981,0.00008944113,0.001846476,0.0023883,0.9930501,0.00001539894],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0004201758,0.9955051,0.0006739676,0.0004977684,0.0004018017,0.000006813877,0.00004115868,0.00003234314,0.002420923],"genre_scores_gemma":[0.002531843,0.9946262,0.0005524926,0.000246332,0.0002370936,0.000009010252,0.00007604637,0.000005496354,0.001715391],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002901382,"threshold_uncertainty_score":0.00970608,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04637706713921996,"score_gpt":0.3226428007161094,"score_spread":0.2762657335768894,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}