{"id":"W2891436740","doi":"10.1016/j.cell.2018.08.048","title":"Evolutionary Pressure against MHC Class II Binding Cancer Mutations","year":2018,"lang":"en","type":"article","venue":"Cell","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":219,"is_retracted":false,"has_abstract":false,"ca_institutions":"Canadian Institute for Advanced Research","funders":"National Heart, Lung, and Blood Institute; National Science Foundation of Sri Lanka; National Institute of General Medical Sciences; Canadian Institute for Advanced Research; National Cancer Institute; National Institutes of Health; National Science Foundation","keywords":"Biology; Major histocompatibility complex; MHC class I; Carcinogenesis; CD8; MHC restriction; Genetics; Cytotoxic T cell; Mutation; Immune system; Immunology; Cancer research; Cancer; Gene; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.00006180011,0.0001705692,0.0001977578,0.0001116422,0.0007612037,0.000008924513,0.0002578006,0.0003359772,0.00296518],"category_scores_gemma":[0.00001570441,0.0001568248,0.00007897581,0.0001629763,0.0005370766,0.00008681828,0.0001625188,0.0003050817,0.003561409],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004405981,"about_ca_system_score_gemma":0.0001087317,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008894168,"about_ca_topic_score_gemma":0.00003329261,"domain_scores_codex":[0.9988998,0.0001055528,0.000216376,0.0003236759,0.00002715579,0.0004274293],"domain_scores_gemma":[0.9994154,0.00006159938,0.0001053635,0.0002833969,0.0001116386,0.00002260175],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00003419429,0.0001511079,0.0008177648,0.00001317771,0.0001153955,0.00000290906,0.0005086092,0.00001541095,0.9400425,0.0001740633,0.05722471,0.0009001403],"study_design_scores_gemma":[0.0007280169,0.0001310097,0.0005149142,0.0000138986,0.00006526282,0.00001142244,0.0001625634,0.00002082802,0.4007475,0.00007993869,0.5973653,0.0001592748],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9424676,0.0139499,0.0000444161,0.0005551298,0.003497008,0.000215418,0.0001531114,0.0001792666,0.03893816],"genre_scores_gemma":[0.8793187,0.0001883672,0.00004888304,0.0002594121,0.0001618612,0.00003656202,0.0002347806,0.0000187809,0.1197327],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5401406,"threshold_uncertainty_score":0.9979463,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01227661240769856,"score_gpt":0.2351458516920429,"score_spread":0.2228692392843443,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}