{"id":"W2891436740","doi":"10.1016/j.cell.2018.08.048","title":"Evolutionary Pressure against MHC Class II Binding Cancer Mutations","year":2018,"lang":"en","type":"article","venue":"Cell","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":219,"is_retracted":false,"has_abstract":false,"ca_institutions":"Canadian Institute for Advanced Research","funders":"National Heart, Lung, and Blood Institute; National Science Foundation of Sri Lanka; National Institute of General Medical Sciences; Canadian Institute for Advanced Research; National Cancer Institute; National Institutes of Health; National Science Foundation","keywords":"Biology; Major histocompatibility complex; MHC class I; Carcinogenesis; CD8; MHC restriction; Genetics; Cytotoxic T cell; Mutation; Immune system; Immunology; Cancer research; Cancer; Gene; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006705802,0.0004429982,0.0003269964,0.0009442875,0.000926102,0.0009395723,0.0005609112,0.001074476,0.008677643],"category_scores_gemma":[0.001055729,0.0001755804,0.0002607012,0.0006141163,0.0007042576,0.000484386,0.0009130695,0.001215316,0.0006983671],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006080159,"about_ca_system_score_gemma":0.0004577427,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001066024,"about_ca_topic_score_gemma":0.001406212,"domain_scores_codex":[0.9994286,0.000130286,0.00002441569,0.0001253259,0.0001235631,0.0001678166],"domain_scores_gemma":[0.9994172,0.0001389863,0.0001092516,0.00007454391,0.0001078459,0.0001522849],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009868636,0.0002015345,0.06633174,0.0002436879,0.0003148763,0.004072787,0.0006096589,0.002272675,0.8039687,0.01797444,0.002355403,0.1006677],"study_design_scores_gemma":[0.0004264381,0.003805097,0.5688686,0.0003252267,0.0007861361,0.0417499,0.00342359,0.01294266,0.2069168,0.01258789,0.1479728,0.0001948545],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9822333,0.0008387095,0.002271251,0.001232838,0.0001187449,0.00002927861,0.0001679742,0.00007572692,0.01303215],"genre_scores_gemma":[0.99458,0.0005491487,0.0008329151,0.0006473105,0.0001106404,0.00001191003,0.000124983,0.00004610903,0.003097014],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008677643,"threshold_uncertainty_score":0.02902955,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01227661240769856,"score_gpt":0.2351458516920429,"score_spread":0.2228692392843443,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}