{"id":"W2891444489","doi":"10.1534/genetics.118.301518","title":"Multiple Histone Methyl-Lysine Readers Ensure Robust Development and Germline Immortality in <i>Caenorhabditis elegans</i>","year":2018,"lang":"en","type":"article","venue":"Genetics","topic":"Genetics, Aging, and Longevity in Model Organisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute of General Medical Sciences; National Institutes of Health; Howard Hughes Medical Institute","keywords":"Biology; Caenorhabditis elegans; Genetics; Histone H3; Chromatin; Histone methylation; Histone; Histone methyltransferase; Methylation; EZH2; Epigenetics; DNA methylation; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003440178,0.0002981161,0.0002798707,0.00008208732,0.0001398046,0.0000342143,0.000236276,0.0002612666,0.0000271665],"category_scores_gemma":[0.00008025806,0.0003237136,0.00005337648,0.0001388957,0.000322535,0.000004273765,0.0001970304,0.0001500559,0.00001517054],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004003982,"about_ca_system_score_gemma":0.0001313203,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001067028,"about_ca_topic_score_gemma":0.003633737,"domain_scores_codex":[0.9981545,0.00008128092,0.0004480538,0.0006272193,0.0002182899,0.0004706806],"domain_scores_gemma":[0.9990092,0.0000145217,0.0001173722,0.0005327394,0.0001638714,0.0001622787],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009230407,0.0002741236,0.06716108,0.00009508331,0.000147458,0.00002471374,0.003333637,0.0008740159,0.9111695,0.0000155583,0.003228357,0.01358421],"study_design_scores_gemma":[0.001286573,0.0003070364,0.09054657,0.00002070006,0.00005129039,0.00003880859,0.0002528811,0.0005987623,0.8233817,0.00005772957,0.08283459,0.0006233145],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9854667,0.002508601,0.01104341,0.0002299551,0.0002685341,0.0002384794,0.00002819264,0.00002178359,0.0001942943],"genre_scores_gemma":[0.9525153,0.0005302076,0.04531281,0.0004849519,0.0004206219,0.0000156759,0.0001943182,0.00005094014,0.0004751896],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08778773,"threshold_uncertainty_score":0.9999215,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01872123237317809,"score_gpt":0.2524057343260003,"score_spread":0.2336845019528222,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}