{"id":"W2891444489","doi":"10.1534/genetics.118.301518","title":"Multiple Histone Methyl-Lysine Readers Ensure Robust Development and Germline Immortality in <i>Caenorhabditis elegans</i>","year":2018,"lang":"en","type":"article","venue":"Genetics","topic":"Genetics, Aging, and Longevity in Model Organisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute of General Medical Sciences; National Institutes of Health; Howard Hughes Medical Institute","keywords":"Biology; Caenorhabditis elegans; Genetics; Histone H3; Chromatin; Histone methylation; Histone; Histone methyltransferase; Methylation; EZH2; Epigenetics; DNA methylation; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001597547,0.0003498159,0.0002045976,0.0002602609,0.0002867548,0.0003047542,0.0004049832,0.0003455283,0.0008061666],"category_scores_gemma":[0.0001464381,0.0002324795,0.0002307213,0.00005812141,0.0002653153,0.0001300618,0.0004225238,0.0004669092,0.0004559459],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003926177,"about_ca_system_score_gemma":0.0002853081,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001290486,"about_ca_topic_score_gemma":0.003839471,"domain_scores_codex":[0.9998417,0.00001048364,0.00001463708,0.00004192629,0.00005017072,0.00004107413],"domain_scores_gemma":[0.9996939,0.00002804912,0.0001058701,0.00003738965,0.00003120276,0.0001036193],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003180951,0.00001143538,0.0002334069,0.000008829367,0.000002321378,0.00002787675,0.000003272807,0.00004097785,0.9990917,0.00003769408,0.00004358452,0.0004670929],"study_design_scores_gemma":[0.00001573269,0.0001130187,0.009088693,0.000005355611,0.00001038985,0.0001863952,0.00001475796,0.001423385,0.9871944,0.00003345438,0.001907085,0.000007448076],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947923,0.0003994293,0.002222674,0.00007655779,0.0000315372,0.00002797299,0.0003277385,0.0002504542,0.001871271],"genre_scores_gemma":[0.9955409,0.0001330052,0.001652956,0.00004424035,0.000003901798,0.00001781632,0.0002897469,0.00004212162,0.002275184],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001290486,"threshold_uncertainty_score":0.002848625,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01872123237317809,"score_gpt":0.2524057343260003,"score_spread":0.2336845019528222,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}