{"id":"W2891448801","doi":"10.1200/jco.2016.34.15_suppl.tps9110","title":"A phase 2 study of seribantumab (MM-121) in combination with docetaxel or pemetrexed versus docetaxel or pemetrexed alone in patients with heregulin positive (HRG+), locally advanced or metastatic non-small cell lung cancer (NSCLC).","year":2016,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Docetaxel; Pemetrexed; Internal medicine; Oncology; Regimen; Hazard ratio; Clinical endpoint; Phases of clinical research; Taxane; Progression-free survival; Chemotherapy; Cancer; Randomized controlled trial; Confidence interval; Breast cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00163119,0.002186785,0.002301142,0.0005644837,0.0004083251,0.00103137,0.001200115,0.001601679,0.005661063],"category_scores_gemma":[0.00123582,0.000894161,0.001861556,0.0003819269,0.001038116,0.001490604,0.0004076936,0.003723974,0.001282498],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001148909,"about_ca_system_score_gemma":0.001536963,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008266518,"about_ca_topic_score_gemma":0.002107609,"domain_scores_codex":[0.999514,0.0002113534,0.00002058471,0.000106514,0.00004439954,0.0001030939],"domain_scores_gemma":[0.9992065,0.0001122855,0.0001640095,0.00006234902,0.00005452017,0.0004003259],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.8149884,0.1152549,0.002664766,0.0006125291,0.0008729675,0.0001396669,0.0001891046,0.001151091,0.02356045,0.0002346867,0.002429571,0.03790181],"study_design_scores_gemma":[0.5557364,0.4356741,0.004239947,0.00001838008,0.0003377528,0.000142823,0.00004040042,0.000621157,0.001598181,0.000161482,0.001402865,0.00002654848],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.989867,0.00144397,0.0004858375,0.0005747463,0.0003131453,0.004360058,0.001086927,0.0001007891,0.001767541],"genre_scores_gemma":[0.9823309,0.00173609,0.001990158,0.001189663,0.0003288882,0.005937833,0.002439335,0.00003718549,0.004009796],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005661063,"threshold_uncertainty_score":0.01893818,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04533389530143748,"score_gpt":0.444740856067569,"score_spread":0.3994069607661315,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}