{"id":"W2891462488","doi":"10.1093/ije/dyy140","title":"Mendelian Randomization and mediation analysis of leukocyte telomere length and risk of lung and head and neck cancers","year":2018,"lang":"en","type":"article","venue":"International Journal of Epidemiology","topic":"Telomeres, Telomerase, and Senescence","field":"Medicine","cited_by":60,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency; Sinai Health System; Lunenfeld-Tanenbaum Research Institute; Ontario Institute for Cancer Research; Public Health Ontario; University of Toronto","funders":"Congressionally Directed Medical Research Programs; Fondo para la Investigación Científica y Tecnológica; National Center for Research Resources; National Center for Advancing Translational Sciences; Medical Research Council; Programme Grants for Applied Research; Canadian Cancer Society Research Institute; Pan American Health Organization; National Institutes of Health; National Cancer Institute; Fundación para el Fomento en Asturias de la Investigación Científica Aplicada y la Tecnología; National Institute of Dental and Craniofacial Research; National Institute of Environmental Health Sciences; Universidad de Oviedo; Norges Forskningsråd; Fundação de Amparo à Pesquisa do Estado de São Paulo; Department of Health and Aged Care, Australian Government; National Institute for Health and Care Research; Medical Research and Materiel Command; Georgia Clinical and Translational Science Alliance; Centre International de Recherche sur le Cancer; Princess Margaret Hospital Foundation; Fifth Framework Programme; Cancer Care Ontario; Sundhed og Sygdom, Det Frie Forskningsråd; Herlev Hospital; World Health Organization; Cancer Research UK; Vanderbilt University Medical Center; Kreftforeningen; Niilo Helanderin Säätiö; Comprehensive Cancer Center, City of Hope; College of Graduate and Postdoctoral Studies, University of Saskatchewan; Roy Castle Lung Cancer Foundation; European Commission; Compagnia di San Paolo; Canadian Institutes of Health Research; Center for Clinical and Translational Science, University of Illinois at Chicago; University of Pittsburgh; National Institute on Handicapped Research; Moffitt Cancer Center; Vanderbilt University; Associazione Italiana per la Ricerca sul Cancro; U.S. Department of Defense; H. Lee Moffitt Cancer Center and Research Institute","keywords":"Telomere; Mendelian randomization; Medicine; Head and neck; Oncology; Internal medicine; Pathology; Genetics; Biology; Surgery; Genotype; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.03777564,0.001099313,0.001193775,0.0009907655,0.0004718897,0.0007978209,0.001742708,0.0007121742,0.003134578],"category_scores_gemma":[0.07518758,0.000426111,0.003762401,0.001086511,0.001411374,0.000677301,0.001213731,0.001301563,0.0001560206],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006596014,"about_ca_system_score_gemma":0.001225283,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003313065,"about_ca_topic_score_gemma":0.00185031,"domain_scores_codex":[0.9526485,0.04173241,0.0006608044,0.002809572,0.001280336,0.0008684344],"domain_scores_gemma":[0.9229814,0.06354229,0.005868852,0.006294546,0.000859178,0.0004536332],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.009814397,0.0005137455,0.840398,0.0006181881,0.02321621,0.002063711,0.001365181,0.01542827,0.004538555,0.02393965,0.001682584,0.07642156],"study_design_scores_gemma":[0.004922948,0.007667082,0.5539129,0.0002945395,0.02334351,0.00427313,0.001145199,0.2866614,0.007478118,0.104503,0.005522292,0.0002759627],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8887814,0.001948783,0.1049824,0.00127793,0.0001302859,0.0003752095,0.0006206658,0.0003828962,0.001500365],"genre_scores_gemma":[0.9857773,0.0001608849,0.01339929,0.0001136226,0.00003433366,0.0002200933,0.00009595626,0.00001860782,0.0001799163],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03777564,"threshold_uncertainty_score":0.199779,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02437965804956103,"score_gpt":0.3512591968364434,"score_spread":0.3268795387868823,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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