{"id":"W2891462488","doi":"10.1093/ije/dyy140","title":"Mendelian Randomization and mediation analysis of leukocyte telomere length and risk of lung and head and neck cancers","year":2018,"lang":"en","type":"article","venue":"International Journal of Epidemiology","topic":"Telomeres, Telomerase, and Senescence","field":"Medicine","cited_by":60,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency; Sinai Health System; Lunenfeld-Tanenbaum Research Institute; Ontario Institute for Cancer Research; Public Health Ontario; University of Toronto","funders":"Congressionally Directed Medical Research Programs; Fondo para la Investigación Científica y Tecnológica; National Center for Research Resources; National Center for Advancing Translational Sciences; Medical Research Council; Programme Grants for Applied Research; Canadian Cancer Society Research Institute; Pan American Health Organization; National Institutes of Health; National Cancer Institute; Fundación para el Fomento en Asturias de la Investigación Científica Aplicada y la Tecnología; National Institute of Dental and Craniofacial Research; National Institute of Environmental Health Sciences; Universidad de Oviedo; Norges Forskningsråd; Fundação de Amparo à Pesquisa do Estado de São Paulo; Department of Health and Aged Care, Australian Government; National Institute for Health and Care Research; Medical Research and Materiel Command; Georgia Clinical and Translational Science Alliance; Centre International de Recherche sur le Cancer; Princess Margaret Hospital Foundation; Fifth Framework Programme; Cancer Care Ontario; Sundhed og Sygdom, Det Frie Forskningsråd; Herlev Hospital; World Health Organization; Cancer Research UK; Vanderbilt University Medical Center; Kreftforeningen; Niilo Helanderin Säätiö; Comprehensive Cancer Center, City of Hope; College of Graduate and Postdoctoral Studies, University of Saskatchewan; Roy Castle Lung Cancer Foundation; European Commission; Compagnia di San Paolo; Canadian Institutes of Health Research; Center for Clinical and Translational Science, University of Illinois at Chicago; University of Pittsburgh; National Institute on Handicapped Research; Moffitt Cancer Center; Vanderbilt University; Associazione Italiana per la Ricerca sul Cancro; U.S. Department of Defense; H. Lee Moffitt Cancer Center and Research Institute","keywords":"Telomere; Mendelian randomization; Medicine; Head and neck; Oncology; Internal medicine; Pathology; Genetics; Biology; Surgery; Genotype; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001502961,0.0001084202,0.0007797099,0.0006080609,0.00003389528,0.00000489566,0.00006308853,0.00009494437,0.00003355631],"category_scores_gemma":[0.002895052,0.00008335864,0.00007391674,0.0001707626,0.0004228627,0.0001320099,0.000035853,0.0001400747,9.668097e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005683047,"about_ca_system_score_gemma":0.00008159721,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005554862,"about_ca_topic_score_gemma":0.0003378163,"domain_scores_codex":[0.9984215,0.0002587713,0.0008520897,0.0001711144,0.000180543,0.0001159803],"domain_scores_gemma":[0.9970353,0.00115055,0.001025638,0.00007789121,0.000582397,0.0001282848],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001882173,0.00002222553,0.9714541,0.00003425774,0.002103934,0.000005576805,0.0006484882,0.00008170995,0.001589987,0.0004160526,0.0001332803,0.02162826],"study_design_scores_gemma":[0.005401918,0.0004661984,0.9717025,0.0001183488,0.001023399,0.0001650945,0.0001796786,0.01924671,0.0006751146,0.00055718,0.000384168,0.00007965293],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9916498,0.004882216,0.001998978,0.001084919,0.0001991928,0.00008542973,0.00002825076,0.000003015201,0.00006820636],"genre_scores_gemma":[0.9715319,0.02555444,0.002453669,0.000229042,0.0001971374,0.000001031373,0.00001304403,0.00000600003,0.00001371344],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0215486,"threshold_uncertainty_score":0.3465857,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02437965804956103,"score_gpt":0.3512591968364434,"score_spread":0.3268795387868823,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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