{"id":"W2891465557","doi":"10.7150/thno.24252","title":"Evaluation of antibody fragment properties for near-infrared fluorescence imaging of HER3-positive cancer xenografts","year":2018,"lang":"en","type":"article","venue":"Theranostics","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"Royal University Hospital; University of Saskatchewan","funders":"Western Economic Diversification Canada","keywords":"Biodistribution; Antibody; Chemistry; In vivo; Molecular biology; Fragment crystallizable region; Fluorescence; Immunoglobulin Fab Fragments; Fluorescence-lifetime imaging microscopy; Preclinical imaging; Recombinant DNA; Clearance; Immunoglobulin light chain; In vitro; Biochemistry; Biology; Receptor; Immunology; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005632372,0.000109614,0.0002485534,0.00005200807,0.00006026019,0.000009047609,0.00009375315,0.00003759935,0.00007868959],"category_scores_gemma":[0.0002238069,0.00007870927,0.00007481807,0.0001218178,0.0004584183,0.00004249995,0.0000364578,0.00007177083,0.000002770453],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005005704,"about_ca_system_score_gemma":0.0003818097,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003428945,"about_ca_topic_score_gemma":0.00001178604,"domain_scores_codex":[0.9985373,0.00007763871,0.000263025,0.0001504023,0.0007617607,0.0002098858],"domain_scores_gemma":[0.9974721,0.00009549218,0.0001029873,0.0001690605,0.002101803,0.00005857447],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002293095,0.0002881746,0.03588765,0.0005035489,0.0003212594,0.000002290873,0.004428931,0.00004301387,0.8813109,0.000175403,0.0005250303,0.07422071],"study_design_scores_gemma":[0.002241791,0.001079419,0.08174416,0.001187424,0.0004764368,0.000006186574,0.0002330829,0.0643549,0.8464763,0.0005340453,0.001510059,0.0001561995],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932762,0.00349526,0.0006633638,0.0006407498,0.0001876615,0.001073514,0.00007819085,0.00002764564,0.000557379],"genre_scores_gemma":[0.9969271,0.0002438782,0.00208043,0.0001178529,0.0002717326,0.00003885523,0.00002249507,0.00003106145,0.000266593],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07406452,"threshold_uncertainty_score":0.3209671,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06328648797489574,"score_gpt":0.385975430650546,"score_spread":0.3226889426756503,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}