{"id":"W2891482452","doi":"10.1124/jpet.118.249516","title":"A Multicentre, Randomized, Double-Blind, Placebo-Controlled, Crossover Study To Investigate the Efficacy, Safety, Tolerability, and Pharmacokinetics of Repeat Doses of Inhaled Nemiralisib in Adults with Persistent, Uncontrolled Asthma","year":2018,"lang":"en","type":"article","venue":"Journal of Pharmacology and Experimental Therapeutics","topic":"Asthma and respiratory diseases","field":"Medicine","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"Discovery Centre","funders":"","keywords":"Medicine; Tolerability; Placebo; Crossover study; Asthma; Spirometry; Pharmacokinetics; Clinical endpoint; Anesthesia; Inhalation; Internal medicine; Pharmacodynamics; Vital capacity; Randomized controlled trial; Adverse effect; Gastroenterology; Pharmacology; Lung; Diffusing capacity; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00239891,0.001539082,0.003911027,0.000353672,0.0007315567,0.0008641602,0.00100705,0.002076721,0.004319295],"category_scores_gemma":[0.00239136,0.0009425782,0.001638247,0.0004326981,0.001453974,0.001178148,0.0004523562,0.002514666,0.001006454],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006853463,"about_ca_system_score_gemma":0.001520819,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009348186,"about_ca_topic_score_gemma":0.00204375,"domain_scores_codex":[0.9989441,0.000446254,0.00009705356,0.0002714399,0.0001055527,0.0001356649],"domain_scores_gemma":[0.9984083,0.0003518793,0.0003510437,0.0002096558,0.000153063,0.0005262297],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9708176,0.01466032,0.001013096,0.0003045878,0.0006100322,0.00004301321,0.00006817447,0.0001259128,0.005168741,0.00004243053,0.0003452521,0.006800823],"study_design_scores_gemma":[0.8820248,0.1140041,0.002972591,0.000008383817,0.000250197,0.00002463723,0.00001406183,0.0001314985,0.0002561291,0.00003865972,0.0002648979,0.00001005632],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9888283,0.002017742,0.0007495481,0.0003495524,0.0003877385,0.005696011,0.0007159762,0.0000965177,0.001158616],"genre_scores_gemma":[0.9858474,0.001133649,0.002334432,0.001191419,0.000449422,0.006296643,0.0008995502,0.00002227283,0.001825282],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004319295,"threshold_uncertainty_score":0.01444942,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02374771953728825,"score_gpt":0.3474208291005089,"score_spread":0.3236731095632206,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}