{"id":"W2891493876","doi":"10.1073/pnas.1813461115","title":"Building immune tolerance through DNA vaccination","year":2018,"lang":"en","type":"letter","venue":"Proceedings of the National Academy of Sciences","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; Canadian Institutes of Health Research; Government of Canada; Muscular Dystrophy Association","keywords":"Vaccination; Immune system; DNA vaccination; DNA; Biology; Immune tolerance; Immunology; Virology; Genetics; Immunization","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001595794,0.000356262,0.0004568471,0.0002176656,0.0007537869,0.001193238,0.0006131527,0.00642493,0.00765025],"category_scores_gemma":[0.005635096,0.0002249592,0.0003452943,0.00008566237,0.002034979,0.0016382,0.001114389,0.009654005,0.00395141],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001026729,"about_ca_system_score_gemma":0.000443539,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002244545,"about_ca_topic_score_gemma":0.0003742358,"domain_scores_codex":[0.9993124,0.0002503538,0.0000412324,0.00008919501,0.000192382,0.0001144598],"domain_scores_gemma":[0.9983531,0.001042783,0.0001031859,0.0001541766,0.0001728846,0.0001738393],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005869957,0.0003041204,0.0009194259,0.0003504528,0.00006648523,0.001620541,0.0002745522,0.000526651,0.01318649,0.08535407,0.7454422,0.1513681],"study_design_scores_gemma":[0.0005069754,0.0004793058,0.0005207151,0.0001600981,0.00003380169,0.001534563,0.0001422583,0.001416036,0.01248476,0.07637215,0.9063161,0.00003319068],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.01816427,0.02262673,0.008277661,0.8480316,0.0610339,0.0001153292,0.0001727379,0.0005411199,0.04103655],"genre_scores_gemma":[0.2247922,0.01470372,0.003738313,0.6532561,0.03653391,0.0003327287,0.0002077386,0.0001505751,0.0662847],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.00765025,"threshold_uncertainty_score":0.02559268,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02536237242848541,"score_gpt":0.3049191122781444,"score_spread":0.279556739849659,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}