{"id":"W2891563855","doi":"10.1007/978-1-4939-8739-9_14","title":"Profiling of MicroRNA and Protein from Purified Synaptoneurosomes in a Neurodegenerative Disease Model","year":2018,"lang":"en","type":"book-chapter","venue":"Neuromethods","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Manitoba; Public Health Agency of Canada","funders":"","keywords":"microRNA; Neurodegeneration; Biology; RNA; Proteome; Messenger RNA; Neuroscience; Cell biology; Disease; Synapse; Bioinformatics; Genetics; Gene; Medicine; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001642047,0.0003029304,0.0002666904,0.0003164553,0.0002091861,0.0004441803,0.0001902997,0.0003573251,0.00220875],"category_scores_gemma":[0.0001255364,0.0001837807,0.0002825034,0.0003392343,0.0001399034,0.0003332394,0.0002282674,0.0005401174,0.001408279],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002719777,"about_ca_system_score_gemma":0.0001942245,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002506667,"about_ca_topic_score_gemma":0.0010663,"domain_scores_codex":[0.9999126,0.000007817144,0.000004953748,0.0000285591,0.00003742334,0.000008591334],"domain_scores_gemma":[0.9999542,0.00002225381,0.000006369599,0.000003766779,0.000008541025,0.000004848537],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004923087,0.000008287442,0.000165317,0.00007043419,0.0000054536,0.00004252324,0.0000209337,0.00006972756,0.9857821,0.0005596391,0.0009767263,0.01224964],"study_design_scores_gemma":[0.00001034458,0.000146874,0.008521268,0.00003232722,0.00004555761,0.0006676228,0.00006406799,0.001702612,0.9230729,0.001387924,0.06432287,0.00002552744],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5471436,0.06902526,0.2798373,0.003474597,0.001898083,0.000299517,0.01918446,0.002767361,0.07636984],"genre_scores_gemma":[0.4697842,0.0458373,0.2396642,0.002743316,0.000347455,0.0005716096,0.02140221,0.001466668,0.2181831],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00220875,"threshold_uncertainty_score":0.007388949,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06867957567940747,"score_gpt":0.3435788675656751,"score_spread":0.2748992918862676,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}