{"id":"W2891585489","doi":"10.1080/19490976.2018.1506667","title":"Effective fecal microbiota transplantation for recurrent <i>Clostridioides difficile</i> infection in humans is associated with increased signalling in the bile acid-farnesoid X receptor-fibroblast growth factor pathway","year":2018,"lang":"en","type":"article","venue":"Gut Microbes","topic":"Clostridium difficile and Clostridium perfringens research","field":"Medicine","cited_by":56,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity; University of Alberta","funders":"Engineering and Physical Sciences Research Council; Medical Research Council; University of Nottingham; Alberta Health Services","keywords":"Farnesoid X receptor; Bile acid; FGF19; Fibroblast growth factor; Biology; Gut flora; Fecal bacteriotherapy; Transplantation; Downregulation and upregulation; G protein-coupled bile acid receptor; Receptor; Internal medicine; Microbiology; Endocrinology; Immunology; Clostridium difficile; Biochemistry; Nuclear receptor; Medicine; Transcription factor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006894832,0.0004417106,0.0005760951,0.0004611868,0.0002675382,0.0001052008,0.0002121141,0.0002981403,0.0001107901],"category_scores_gemma":[0.0003344874,0.0003198402,0.0002094367,0.001072882,0.0002459988,0.0001464402,0.00003481231,0.000623252,0.00003707859],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006300965,"about_ca_system_score_gemma":0.0002497365,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001151036,"about_ca_topic_score_gemma":0.004025565,"domain_scores_codex":[0.9971869,0.0003826923,0.0005799577,0.0007046988,0.0004044948,0.0007412767],"domain_scores_gemma":[0.9984047,0.0006063347,0.0001790983,0.0002854099,0.0004068905,0.0001175143],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002366071,0.001020203,0.01475302,0.0003476633,0.0001003893,0.00002572695,0.003268692,0.000004671507,0.975719,0.00001130284,0.0007778215,0.001605427],"study_design_scores_gemma":[0.005562623,0.003361884,0.06761491,0.001514999,0.00007845184,0.00003304724,0.0003022715,0.0000873082,0.9205441,0.00001398846,0.0005059913,0.0003804493],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954357,0.0002437793,0.0002395277,0.0003276887,0.0001138739,0.002808868,0.0006242261,0.00007444147,0.0001318806],"genre_scores_gemma":[0.9979387,0.0002932248,0.00009465437,0.0002073001,0.0003168205,0.0003407086,0.0007064661,0.00006366918,0.00003846184],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05517494,"threshold_uncertainty_score":0.9999254,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01702367175054766,"score_gpt":0.2686225704606767,"score_spread":0.2515988987101291,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}