{"id":"W2891585489","doi":"10.1080/19490976.2018.1506667","title":"Effective fecal microbiota transplantation for recurrent <i>Clostridioides difficile</i> infection in humans is associated with increased signalling in the bile acid-farnesoid X receptor-fibroblast growth factor pathway","year":2018,"lang":"en","type":"article","venue":"Gut Microbes","topic":"Clostridium difficile and Clostridium perfringens research","field":"Medicine","cited_by":56,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity; University of Alberta","funders":"Engineering and Physical Sciences Research Council; Medical Research Council; University of Nottingham; Alberta Health Services","keywords":"Farnesoid X receptor; Bile acid; FGF19; Fibroblast growth factor; Biology; Gut flora; Fecal bacteriotherapy; Transplantation; Downregulation and upregulation; G protein-coupled bile acid receptor; Receptor; Internal medicine; Microbiology; Endocrinology; Immunology; Clostridium difficile; Biochemistry; Nuclear receptor; Medicine; Transcription factor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002534641,0.0002939796,0.0004772985,0.0001809639,0.0001894257,0.0003131805,0.0001374585,0.0002779101,0.001174907],"category_scores_gemma":[0.0001971068,0.0000610896,0.0002896202,0.0001243484,0.0002472576,0.000150172,0.000204583,0.0005641836,0.0001852554],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002195618,"about_ca_system_score_gemma":0.0002826268,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002555696,"about_ca_topic_score_gemma":0.0006434087,"domain_scores_codex":[0.9998863,0.00002401975,0.000007610443,0.00001779218,0.00002659664,0.00003766148],"domain_scores_gemma":[0.9998796,0.00001359735,0.00004686497,0.000009128413,0.000008531627,0.00004223795],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.004414185,0.001162895,0.003238167,0.0004622026,0.00006866852,0.0004309119,0.0000666399,0.0001693839,0.9055866,0.0001630502,0.0004819025,0.08375544],"study_design_scores_gemma":[0.0007639146,0.09107418,0.208708,0.0003030764,0.0003796726,0.006280285,0.0005523307,0.001746704,0.6726977,0.0004096577,0.01702964,0.0000547302],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.992804,0.004316654,0.00123729,0.0001996222,0.00006586829,0.00004799741,0.00007514702,0.00008050497,0.001172811],"genre_scores_gemma":[0.9957772,0.001728504,0.001504185,0.0001070682,0.00003339318,0.00003226009,0.0001845854,0.00001279126,0.0006198504],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001174907,"threshold_uncertainty_score":0.003930449,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01702367175054766,"score_gpt":0.2686225704606767,"score_spread":0.2515988987101291,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}